Synthesis and hypotensive activity of some 6-(substituted aryl)-4-methyl-2,3-dihydropyridazin-3-ones
6-(Substituted aryl)-4-methyl-2,3-dihydropyridazin-3-ones are synthesized by cyclisation of appropriate β-(substituted aroyl)-2-methylene propionate with hydrazine hydrate in the presence of sodium acetate. The title compounds are tested for hypotensive activity, non-invasively, by tail-cuff method and are found to possess significant hypotensive activity in normotensive rats.
Siddiqui, Anees A.,Wani, Sachin M.
p. 1574 - 1579
(2007/10/03)
Synthesis, structure and hypocholesterolemic activity of a series of substituted 4-aryl, 4-oxo butyric acids
-
Cousse,Mouzin,Rieu,et al.
p. 45 - 57
(2007/10/02)
More Articles about upstream products of 19340-35-3