Partial Synthesis of New Ergoline Derivatives from Clavine Alkaloids, III: O-Acyl- and O-Alkyl-1,6-dimethyl-8-(hydroxymethyl)ergol-9-enes
Elymoclavine (1), lysergole (2) and O-acyllysergoles are primarily methylated at the indole nitrogen when reacted with potassium and methyl iodide in ammonia.By variation of the reaction conditions, 1 and 2 can also by methylated at the hydroxy group.Thus, 1-methyl lysergole ethers can by prepared by the same method with different alkyl iodides.On the other hand, ester syntheses according to Williamson starting from 17-halogenoergolenes are not successful.
Eich, Eckart
p. 781 - 788
(2007/10/02)
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