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Benzenesulfonamide, N-[(4-fluorophenyl)methylene]-4-methyl-, also known as 4-methyl-N-[(4-fluorophenyl)methylene]benzenesulfonamide, is a chemical compound with the molecular formula C14H12FNO2S. It is a derivative of benzenesulfonamide, featuring a 4-methyl group and a (4-fluorophenyl)methylene bridge connecting the benzene ring to the sulfonamide group. Benzenesulfonamide, N-[(4-fluorophenyl)methylene]-4-methyl- is primarily used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals, particularly in the production of herbicides and other chemical products. Its unique structure and properties make it a valuable component in the development of new and improved chemical compounds for various applications.

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  • 193675-43-3 Structure
  • Basic information

    1. Product Name: Benzenesulfonamide, N-[(4-fluorophenyl)methylene]-4-methyl-
    2. Synonyms:
    3. CAS NO:193675-43-3
    4. Molecular Formula: C14H12FNO2S
    5. Molecular Weight: 277.319
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 193675-43-3.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: Benzenesulfonamide, N-[(4-fluorophenyl)methylene]-4-methyl-(CAS DataBase Reference)
    10. NIST Chemistry Reference: Benzenesulfonamide, N-[(4-fluorophenyl)methylene]-4-methyl-(193675-43-3)
    11. EPA Substance Registry System: Benzenesulfonamide, N-[(4-fluorophenyl)methylene]-4-methyl-(193675-43-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 193675-43-3(Hazardous Substances Data)

193675-43-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 193675-43-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,3,6,7 and 5 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 193675-43:
(8*1)+(7*9)+(6*3)+(5*6)+(4*7)+(3*5)+(2*4)+(1*3)=173
173 % 10 = 3
So 193675-43-3 is a valid CAS Registry Number.

193675-43-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name N-tosyl-(4-fluorophenyl)methanimine

1.2 Other means of identification

Product number -
Other names p-chlorobenzylidene-4-methylbenzenesulfoamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:193675-43-3 SDS

193675-43-3Relevant articles and documents

Palladium-Catalyzed Regioselective and Stereospecific Ring-Opening Suzuki-Miyaura Arylative Cross-Coupling of 2-Arylazetidines with Arylboronic Acids

Takeda, Youhei,Toyoda, Kazuya,Sameera,Tohnai, Norimitsu,Minakata, Satoshi

supporting information, p. 2796 - 2805 (2021/04/15)

We have developed a palladium-catalyzed regioselective and enantiospecific ring-opening Suzuki–Miyaura arylative cross-coupling of N-tosyl-2-arylazetidines to give enantioenriched 3,3-diarylpropylamines. This reaction represents an example of transition-metal-catalyzed ring-opening cross-coupling using azetidines as a non-classical alkyl electrophile. Density functional theory rationalized the mechanism of the full catalytic cycle, which consists of the selectivity-determining ring opening of the azetidine, reaction with water, rate-determining transmetalation, and reductive elimination. Transition states of the selectivity-determining ring-opening step were systematically determined by the multi-component artificial force induced reaction (MC-AFIR) method to explain the regioselectivity of the reaction. (Figure presented.).

Facile synthesis, antimicrobial and antiviral evaluation of novel substituted phenyl 1,3-thiazolidin-4-one sulfonyl derivatives

Mandal, Milan Kumar,Ghosh, Swagatika,Naesens, Lieve,Bhat, Hans Raj,Singh, Udaya Pratap

, (2021/07/17)

A series of novel substituted phenyl 1, 3-thiazolidin-4-one sulfonyl derivatives 5 (a-t) were synthesized and screened for their in-vitro anti-microbial and anti-viral activity. The result of the anti-microbial assay demonstrated compounds 5d, 5f, 5g, 5h,

The diastereoselective synthesis of 2,3-diaryl-3-cyano-substituted pyrrolidines via the MgI2 mediated ring expansion of aryl cyclopropyl nitriles

Stead, Darren

supporting information, (2020/09/04)

The MgI2 mediated reaction of aryl substituted cyclopropyl nitriles with tosyl aldimines to give 2,3-diaryl-3-cyano-substituted pyrrolidines has been demonstrated. In all cases, the trans-diastereoisomer was determined to be the major product.

Iron-based nanomaterials used as magnetic mesoporous nanocomposites to catalyze the preparation of N-sulfonylimines

Ashouri, Akram,Samadi, Saadi,Nasiri, Behzad,Bahrami, Zohre

, p. 549 - 556 (2019/08/01)

A new magnetic nanocatalyzed synthetic method for the synthesis of aldimines was evidenced. The reaction was carried out in a Schlenk tube under reflux conditions using various solvents and different nanomaterials as catalysts. In these reactions, an exce

NHC ligand-enabled Ni-catalyzed reductive coupling of alkynes and imines using isopropanol as a reductant

Yao, Wei-Wei,Li, Ran,Li, Jiang-Fei,Sun, Juan,Ye, Mengchun

supporting information, p. 2240 - 2244 (2019/05/17)

A nickel-catalyzed reductive coupling of alkynes and imines using readily available isopropanol as the reducing agent was developed. The use of a sterically bulky and electron-rich carbene ligand (AnIPr) significantly promotes the reaction, providing various multi-substituted allylic amines in 23-89% yield and the corresponding chiral ligand (AnIPr-3) can afford the products in 51-95% ee.

Ruthenium-Catalyzed Synthesis of Isoindolinones via Amide-Directed Addition of Aromatic C-H Bonds to Aldimines

Miura, Hiroki,Kimura, Yuriko,Terajima, Sachie,Shishido, Tetsuya

supporting information, p. 2807 - 2811 (2019/02/01)

Ruthenium-catalyzed addition of aromatic C-H bonds to aldimines is described. [RuCl2(p-cymene)]2 functions as an efficient catalyst to promote the coupling of aryl amides with aldimines in the presence of a catalytic amount of base to give the corresponding isoindolinone derivatives. The nature of the substituent at the N-atom of the amides is crucial for the efficient conversion of the substrates, and a p-toluenesulfonyl group is the functionality of choice. A variety of amides and aldimines participated in the present Ru-catalyzed reaction to furnish the corresponding isoindolinones in moderate to high yield.

Enantioselective Aza-Reformatsky Reaction with Ketimines

Maestro, Aitor,Martinez De Marigorta, Edorta,Palacios, Francisco,Vicario, Javier

supporting information, p. 9473 - 9477 (2019/11/28)

Here, an enantioselective aza-Reformatsky reaction using acyclic ketimine substrates is presented. Using α-phosphorated ketimines as electrophilic substrates and a simple BINOL-derived ligand, phosphorated analogues of aspartic acid holding chiral tetrasubstituted carbons are efficiently obtained with excellent enantioselectivity through an asymmetric organocatalytic Reformatsky-type reaction. The phosphorated analogues of aspartic acid have been used for the synthesis of phosphorus-containing enantiopure tetrasubstituted β-lactams.

Practical N-hydroxyphthalimide-mediated oxidation of sulfonamides to N-sulfonylimines

Wang, Jian,Yi, Wen-Jing

, (2019/11/02)

A new method to prepare sulfonylimines through the oxidation of sulfonamides mediated by N-hydroxyphthalimide under mild conditions has been developed. Compared to reported oxidation methods, broader substrates scope and milder conditions were achieved in

Visible-Light-Mediated Decarboxylative Benzylation of Imines with Arylacetic Acids

Guo, Jing,Wu, Qiao-Lei,Xie, Ying,Weng, Jiang,Lu, Gui

, p. 12559 - 12567 (2018/10/20)

A straightforward method for the visible-light-mediated decarboxylative benzylation of imines is reported. The key feature of this method is the use of simple primary, secondary, and tertiary arylacetic acids as precursors of benzyl radicals, enabling the facile benzylation of a variety of imines under mild conditions. A variety of structurally diverse β-arylethylamines (37 examples) was accessed using this method.

Palladium-Catalyzed Direct Intramolecular C-N Bond Formation: Access to Multisubstituted Dihydropyrroles

Jiang, Bing,Meng, Fei-Fan,Liang, Qiu-Ju,Xu, Yun-He,Loh, Teck-Peng

supporting information, p. 914 - 917 (2017/02/26)

A palladium-catalyzed intramolecular amination of alkenes with retention of olefin functionalization was achieved under mild reaction conditions. In the presence of palladium catalyst, the tosyl-protected amine can directly couple with a double bond to provide versatile dihydropyrrole derivatives in moderate to excellent yields.

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