cas 193686-76-9, 7-Chloro-1,2,3,4-tetrahydro-1-[(4-methylphenyl)sulfonyl]-5H-1-benzazepin-5-one | Articles data ｜lookchem

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193686-76-9

Articles about 193686-76-9Total 3 be found

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Efficient and promising asymmetric preparation of enantiopure tolvaptan via transfer hydrogenation with robust catalysts
Enantiopure tolvaptan, the first and only oral vasopressin antagonist for hyponatremia has been prepared by using an asymmetric transfer hydrogenation as a key step with HCOOH-Et3N or HCOONa-H2O as the hydrogen donor in open air. Good chemical yields with up to 99% enantioselectivity were obtained with a 1000:1 of S/C in an HCOONa-H2O system. The air and water stable catalysts provide a very promising prospect for industrial application.
Yin, Lu,Zheng, Yourou,Jia, Xian,Li, Xingshu,Chan, Albert S.C.
scheme or table
p. 2390 - 2393
(2010/12/25)

Sequential aza-Claisen rearrangement and ring-closing metathesis as a route to 1-benzazepine derivatives
A synthetic strategy based on sequential application of aza-Claisen rearrangement and ring-closing metathesis reaction as key steps has been developed for the synthesis of various 1-benzazepine derivatives of pharmaceutical relevance. Georg Thieme Verlag
Ghosh, Debalina,Thander, Latibuddin,Ghosh, Sanjay K.,Chattopadhyay, Shital K.
scheme or table
p. 3011 - 3015
(2009/06/27)

7-Chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5- tetrahydro-1H-1-benzazepine (OPC-41061): A potent, orally active nonpeptide arginine vasopressin V2 receptor antagonist
We previously reported a series of benzazepine derivatives as orally active nonpeptide arginine vasopressin (AVP) V2 receptor antagonists. After the lead structure OPC-31260 was structurally evaluated and optimized, the introduction of the 7-Cl moiety on the benzazepine and 2-CH3 on the aminobenzoyl moiety enhanced its oral activity. The new AVP-V2 selective antagonist OPC-41061 was determined to be a potent and orally active agent. Copyright (C) 1999 Elsevier Science Ltd.
Kondo, Kazumi,Ogawa, Hidenori,Yamashita, Hiroshi,Miyamoto, Hisashi,Tanaka, Michinori,Nakaya, Kenji,Kitano, Kazuyoshi,Yamamura, Yoshitaka,Nakamura, Shigeki,Onogawa, Toshiyuki,Mori, Toyoki,Tominaga, Michiaki
p. 1743 - 1754
(2007/10/03)

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193686-73-6
(S)-7-chloro-5-hydroxy-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepine

Chemical Properties

Boiling Point: 536.5 °C at 760 mmHg
Flash Point:278.3 °C
Density: 1.36 g/cm³
Refractive Index: 1.619
PKA: -4.58±0.20(Predicted)
PSA: 62.83000
LogP: 4.96600

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