- Total synthesis of (S)-(+)-Solanone
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Optically active solanone was synthesized from (R)-(+)-p-menthene, and the (S)-configuration was confirmed for the natural product.
- Kohda, Akira,Sato, Tadashi
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- Nickel-catalyzed reductive 1,3-diene formation from the cross-coupling of vinyl bromides
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Facile construction of 1,3-dienes building upon cross-electrophile coupling of two open-chain vinyl halides is disclosed in this work, showing moderate chemoselectivities between the terminal bromoalkenes and internal vinyl bromides. The present method is mild and tolerates a range of functional groups and can be applied to the total synthesis of a tobacco fragrance solanone.
- Sha, Yunfei,Liu, Jiandong,Wang, Liang,Liang, Demin,Wu, Da,Gong, Hegui
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p. 4887 - 4890
(2021/06/16)
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- Diene compound and synthesis method thereof
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The invention provides a synthesis method of a diene compound. The method comprises the following steps: taking beta-alkenyl bromide and alpha/beta-alkenyl bromide as raw materials, adding a catalyst, a ligand, a reducing agent, a halogen ion exchanger and a solvent, and carrying out reductive coupling reaction to obtain the required diene compound. The invention further provides a diene compound. The diene compound and the synthetic method thereof provided by the invention have the advantages of green and environment-friendly catalyst metal, low toxicity, high efficiency, low cost, mild reaction, simple operation and high yield.
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Paragraph 0055-0062
(2021/07/28)
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- (E)-type solanone and preparation method and application thereof
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The invention discloses (E)-type solanone, which has a three-dimensional structural formula shown in the specification, or has a name of (S, E)-5-isopropyl-8-methyl-6, 8-diene-2-one, or has a name of(R, E)-5-isopropyl-8-methyl-6, 8-diene-2-one. The invention also discloses a preparation method of the (E)-type solanone and an application of the (E)-type solanone in perfuming cigarette tobacco shreds.
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Paragraph 0032-0035
(2020/05/02)
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- Metal-Catalyzed Organic Photoreactions. Bond-Cleavage Selectivity and Synthetic Application of the Iron(III) Chloride Catalyzed Photooxidation of Cyclic Olefins
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Photooxidation of olefins in pyridine in the presence of iron(III) chloride produced either α-chloro ketones (type A), gem-dichloro ketones (type B), or α,ω-dichloro ketones (type C), depending upon the substitution pattern of the substrate olefin.The synthetic utility of the type B reaction was demonstrated by the synthesis of some natural products.The synthesis of optically active solanone from D-p-menthene confirmed the D configuration of the natural product.
- Kohda, Akira,Nagayoshi, Kazuo,Maemoto, Kazuo,Sato, Tadashi
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p. 425 - 432
(2007/10/02)
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