- Preparation method of 2, 4, 6-trichlorobenzonitrile
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The invention provides a preparation method of 2, 4, 6-trichlorobenzonitrile. The method comprises the following steps: (1) contacting 1, 3, 5-trichlorobenzene with a bromination reagent in an aprotic solvent to carry out bromination reaction to prepare 2-bromo-1, 3, 5-trichlorobenzene; and (2) enabling the 2-bromo-1, 3, 5-trichlorobenzene to make contact with a cyaniding reagent in a dipolar aprotic solvent to carry out cyaniding reaction so as to prepare the 2, 4, 6-trichlorobenzonitrile. The 1, 3, 5-trichlorobenzene which is low in price and easy to obtain is used as the raw material, the bromination reaction and the cyanidation reaction are sequentially carried out in the specific solvent, the raw material conversion rate is high, and the 2, 4, 6-trichlorobenzonitrile has the advantages of high yield and purity, short route, simple process, low cost, environmental protection and the like.
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Paragraph 0030-0032; 0036-0039
(2021/06/26)
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- PROCESS FOR THE PREPARATION OF ORGANIC HALIDES
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The present invention provides a halo-de-carboxylation process for the preparation of organic chlorides, organic bromides and mixtures thereof, from their corresponding carboxylic acids, using a chlorinating agent selected from trichloroisocyanuric acid (TCCA), dichloroisocyanuric acid (DCCA), or combination thereof, and a brominating agent.
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Paragraph 00143
(2017/08/01)
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