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194034-59-8

2-AMino-6-chloropurine-9-(2'-O-Methyl)riboside is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 194034-59-8 Structure

  • Basic information

    1. Product Name: 2-AMino-6-chloropurine-9-(2'-O-Methyl)riboside
    2. Synonyms: 2-AMino-6-chloropurine-9-(2'-O-Methyl)riboside;2-AMino-6-chloro-9-(2'-O -Methyl-beta-D-ribofuranosyl)-9H-purine;6-chloro-9-(2-O-Methyl-beta-D-ribofuranosyl)-9H-purin-2-aMine
    3. CAS NO:194034-59-8
    4. Molecular Formula: C11H14ClN5O4
    5. Molecular Weight: 315.71296
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 194034-59-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-AMino-6-chloropurine-9-(2'-O-Methyl)riboside(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-AMino-6-chloropurine-9-(2'-O-Methyl)riboside(194034-59-8)
    11. EPA Substance Registry System: 2-AMino-6-chloropurine-9-(2'-O-Methyl)riboside(194034-59-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 194034-59-8(Hazardous Substances Data)

194034-59-8 Usage

Classification

Purine nucleoside

Derivative of

Adenine

Common Use

Scientific research and pharmaceutical development

Application

Precursor for synthesis of nucleoside analogs

Therapeutic Potential

Treatment of viral infections and cancer

Chemical Modifications

Addition of chloro group and methyl group

Biochemical Properties Enhancement

Result of chemical modifications

Stability Improvement

Likely due to chemical modifications

Bioavailability Enhancement

Likely due to chemical modifications

Significance

Important chemical tool

Promising Applications

Basic research and medical science

Check Digit Verification of cas no

The CAS Registry Mumber 194034-59-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,4,0,3 and 4 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 194034-59:
(8*1)+(7*9)+(6*4)+(5*0)+(4*3)+(3*4)+(2*5)+(1*9)=138
138 % 10 = 8
So 194034-59-8 is a valid CAS Registry Number.

194034-59-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-amino-6-chloro-9-[2'-O-methyl-β-D-ribofuranosyl]purine

1.2 Other means of identification

Product number -
Other names 2'-O-methyl-2-amino-6-chloropurine riboside

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:194034-59-8 SDS

194034-59-8Relevant articles and documents

Improved synthetic approaches toward 2'-O-methyl-adenosine and guanosine and their N-acyl derivatives

Beigelman, Leonid,Haeberli, Peter,Sweedler, David,Karpeisky, Alexander

, p. 1047 - 1056 (2007/10/03)

We developed several improved approaches toward 2'-O-methyl adenosine and guanosine and their N-acyl derivatives. (a) Transglycosylation of N4- acetyl-5', 3'-di-O-acetyl-2'-O-methyl cytidine with N6-Bz-adenine provided N6-benzoyl-5'3'-di-O-acetyl-2'-O-methyl adenosine in 50% yield. (b) Regioselective methylation of 2-amino-6-chloro purine riboside with MeI/NaH followed by hydrolysis provided 2'-O-Me-guanosine in high yield. The same 2'- O-Me-precursor was transformed into 2'-O-Me-adenosine in 58% yield. (c) Very efficient transformation of 2,6-diamino-purine riboside into N2-isobutyryl (isopropylphenoxyacetyl) 2'-O-Me-guanosine through methylation of 5',3'-O- TIPDSi derivative followed by selective N2-acylation, deamination and desylilation provided target compounds in 70% combined yield. (d) Mg2+ and Ag+ directed methylation of N1-Bzl-guanosine proceeded in >80% yield with ratio of 2'-O-Me-3'-O-Me=9:1. The same methylation of adenosine with Ag+ and Sr2+ acetylacetonates provided 2'-O-Me-adenosine in 75-80% yield. (C) 2000 Elsevier Science Ltd.

Chemical syntheses of 2'-O-methoxy purine nucleosides

-

, (2008/06/13)

Several processes for the chemical synthesis of 2'-O-methoxy purine nucleosides are herein disclosed.

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