194349-17-2

Basic information

• Product Name: Norleucine,4-fluoro-5-methyl-(9CI)
• Synonyms: Norleucine,4-fluoro-5-methyl-(9CI)
• CAS NO: 194349-17-2
• Molecular Formula: C7H14FNO2
• Molecular Weight: 163.1899632
• Product Categories: GLYCINESCAFFOLD
• Mol File: 194349-17-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Norleucine,4-fluoro-5-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Norleucine,4-fluoro-5-methyl-(9CI)(194349-17-2)
• EPA Substance Registry System: Norleucine,4-fluoro-5-methyl-(9CI)(194349-17-2)

Safety Data

• Hazardous Substances Data: 194349-17-2(Hazardous Substances Data)

Relevant articles and documents

Stereoselective Synthesis of Some γ- and δ-Fluoro-α-amino Acids

(R)-(-)-2-Amino-4-fluorobutyric acid (4c) (32percent ee) and six of its homologues 9 have been synthesized by diastereoselective alkylation (54-72percent yield) of (R)-(+)-camphor-based glycine ester imines 1 with 1-bromo-2-fluoro-alkanes 6, at low temperature, followed by deprotection.Similarly 1-bromo-3-fluoropropane was used for the preparation of (R)-(-)-5-fluoronorvaline (4d) (42percent ee).With 1-bromo-2-fluoropropane (6a) and its homologues (prepared by bromofluorination of 1-alkenes) partial resolution occurs in the alkylation step, yielding mixtures of four diastereomers.Using (R)-1-bromo-2-fluoro-4-methylpentane two diastereomeric alkylation products are formed (58percent de).The overall yield of the three-step procedure varied from 10percent to 32percent. - Keywords: Chiral auxiliaries; Glycine ester imines; Alkylations; Bromofluoro alkanes; Triethylamine tris(hydrofluoride)