A convenient access to N,N-disubstituted amides derived from (1R,3S)-(-)-2,2-dimethyl-3-formylcyclopropane-1-carboxylic acid
Enantiopure N,N-disubstituted amides are obtained in good yield from (1R,3S)-(-)-2,2-dimethyl-3-formylcyclopropane-1-carboxylic acid in three steps: dithiane protection of the aldehyde function; amidation of the carboxylic acid function; dethioketalizatio