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CAS

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194804-80-3

2,4-Difluoro-3-hydroxybenzoic acid methyl ester is an organic compound characterized by the presence of two fluorine atoms at the 2nd and 4th positions of the benzene ring, a hydroxyl group at the 3rd position, and a methyl ester functional group. This molecule is known for its potential applications in the pharmaceutical industry due to its unique structural features and reactivity.

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  • 194804-80-3 Structure

  • Basic information

    1. Product Name: 2,4-DIFLUORO-3-HYDROXYBENZOIC ACID METHYL ESTER
    2. Synonyms: 2,4-DIFLUORO-3-HYDROXYBENZOIC ACID METHYL ESTER
    3. CAS NO:194804-80-3
    4. Molecular Formula: C8H6F2O3
    5. Molecular Weight: 188.1282464
    6. EINECS: N/A
    7. Product Categories: Aromatic Esters
    8. Mol File: 194804-80-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2,4-DIFLUORO-3-HYDROXYBENZOIC ACID METHYL ESTER(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2,4-DIFLUORO-3-HYDROXYBENZOIC ACID METHYL ESTER(194804-80-3)
    11. EPA Substance Registry System: 2,4-DIFLUORO-3-HYDROXYBENZOIC ACID METHYL ESTER(194804-80-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 194804-80-3(Hazardous Substances Data)

194804-80-3 Usage

Uses

Used in Pharmaceutical Industry:
2,4-Difluoro-3-hydroxybenzoic acid methyl ester is used as a reactant for the preparation of fluoroquinolone drugs, specifically Garenoxacin. This application is based on its ability to serve as a key intermediate in the synthesis of the drug, which is a potent antibiotic used to treat various bacterial infections. The presence of fluorine atoms in the molecule enhances the drug's activity and pharmacokinetic properties, making it more effective against a wide range of bacterial pathogens.

Check Digit Verification of cas no

The CAS Registry Mumber 194804-80-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,4,8,0 and 4 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 194804-80:
(8*1)+(7*9)+(6*4)+(5*8)+(4*0)+(3*4)+(2*8)+(1*0)=163
163 % 10 = 3
So 194804-80-3 is a valid CAS Registry Number.

194804-80-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name Methyl 2,4-difluoro-3-hydroxybenzoate

1.2 Other means of identification

Product number -
Other names 2,4-Dicyclopentyl-quinoline-3-carboxylic acid methyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:194804-80-3 SDS

194804-80-3Downstream Products

194804-80-3Relevant articles and documents

2-Chloro-2,2-difluoroacetophenone: A non-ODS-based difluorocarbene precursor and its use in the difluoromethylation of phenol derivatives

Zhang, Laijun,Zheng, Ji,Hu, Jinbo

, p. 9845 - 9848 (2007/10/03)

A novel and non-ODS-based (ODS = ozone-depleting substance) preparation of 2-chloro-2,2-difluoroacetophenone (1) was achieved in high yield by using 2,2,2-trifluoroacetophenone as the starting material. Compound 1 was found to act as a good difluorocarbene reagent, which readily reacts with a variety of structurally diverse phenol derivatives 4 in the presence of potassium hydroxide or potassium carbonate to produce aryl difluoromethyl ethers 5 in good yields. This new and easy-to-handle synthetic methodology offers an environmentally friendly alternative to other Freon- or Halon-based difluoromethylating approaches.

Quinolonecarboxylic acid derivatives or salts thereof

-

, (2008/06/13)

PCT No. PCT/JP97/00317 Sec. 371 Date Aug. 10, 1998 Sec. 102(e) Date Aug. 10, 1998 PCT Filed Feb. 7, 1997 PCT Pub. No. WO97/29102 PCT Pub. Date Aug. 14, 1997The present invention relates to a quinolone-carboxylic acid derivative represented by the general

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