- CHIRAL FUSED [1,2]IMIDAZO[4,5-c] RING COMPOUNDS
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Fused [1,2]imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridines) with a -CH(-X1-R1)-group in the fused ring at the 1-position of the imidazo ring, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
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Page/Page column 148
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- SUBSTITUTED CHIRAL FUSED [1,2]IMIDAZO[4,5-C] RING COMPOUNDS
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Substituted fused [1,2]imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridines) with a -CH(-R1)- group in the fused ring at the 1-position of the imidazo ring, wherein Rl includes a functional group, for example, an amide, sulfonamide, urea, carbamate, ester, ketone, ether, a thio analog of the forgoing, sulfone, oxime, or hydroxylamine, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
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Page/Page column 141-142
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- Solvent-free Phase Transfer Catalysis. Improvements on serine O-alkylation
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An efficient method of preparing O-alkyl serine methyl esters using solvent-free Phase Transfer Catalysis is described. This technique affords high reaction yields with both activated and non-activated alkyl halides, and no racemization is observed. The one-step procedure can be used to advantage over the usual two-step (allylation-hydrogenation) method. Springer-Verlag Iberica 1997.
- Diez-Barra, Enrique,De La Hoz, Antonio,Sanchez-Verdu, Prado
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p. 145 - 146
(2007/10/03)
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