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Oregon Green 488 carboxylic acid is a novel fluorinated fluorescein agent characterized by its unique fluorescent properties. It is designed for use in biological experiments where fluorescein needs to be covalently attached to various biomolecules such as peptides, proteins (particularly antibodies), nucleotides, oligonucleotides, drugs, hormones, lipids, and other biomolecules. This versatile compound allows for the tracking and visualization of these molecules within biological systems, making it a valuable tool in research and diagnostics.

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  • 195136-52-8 Structure
  • Basic information

    1. Product Name: Oregon Green 488 carboxylic acid
    2. Synonyms: Oregon Green 488 carboxylic acid
    3. CAS NO:195136-52-8
    4. Molecular Formula: C21H10F2O7
    5. Molecular Weight: 412.3
    6. EINECS: N/A
    7. Product Categories: Fluorescent;Xanthene
    8. Mol File: 195136-52-8.mol
  • Chemical Properties

    1. Melting Point: >250°C
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /Solid
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: Solubility Insoluble in water; soluble in N,N-dimethylformamide
    9. PKA: 4.7(at 25℃)
    10. CAS DataBase Reference: Oregon Green 488 carboxylic acid(CAS DataBase Reference)
    11. NIST Chemistry Reference: Oregon Green 488 carboxylic acid(195136-52-8)
    12. EPA Substance Registry System: Oregon Green 488 carboxylic acid(195136-52-8)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 195136-52-8(Hazardous Substances Data)

195136-52-8 Usage

Uses

Used in Biomedical Research:
Oregon Green 488 carboxylic acid is used as a fluorescent label for various biomolecules in biomedical research. The application reason is its ability to provide a bright and stable fluorescence signal, which aids in the detection, tracking, and analysis of the labeled molecules within biological systems.
Used in Drug Development:
In the pharmaceutical industry, Oregon Green 488 carboxylic acid is used as a fluorescent marker for drug molecules. The application reason is its capacity to enhance the visualization and monitoring of drug distribution, uptake, and interaction with target cells or tissues, thereby facilitating the evaluation of drug efficacy and safety.
Used in Diagnostics:
Oregon Green 488 carboxylic acid is employed as a diagnostic tool in the development of assays and tests for detecting specific biomolecules or cellular processes. The application reason is its strong fluorescence signal, which allows for sensitive and accurate detection of the target molecules, contributing to the early diagnosis and monitoring of various diseases.
Used in Cell Biology:
In cell biology, Oregon Green 488 carboxylic acid is used as a fluorescent probe for studying cellular processes and interactions. The application reason is its ability to label and visualize specific cellular components, such as organelles, membranes, or proteins, providing valuable insights into cellular functions and mechanisms.
Used in Immunofluorescence:
Oregon Green 488 carboxylic acid is utilized as a fluorescent tag in immunofluorescence techniques, where it is used to label antibodies for the detection of specific antigens in cells or tissues. The application reason is its bright and stable fluorescence, which enables the precise localization and quantification of the target antigens, aiding in the study of various biological processes and disease states.

Check Digit Verification of cas no

The CAS Registry Mumber 195136-52-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,5,1,3 and 6 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 195136-52:
(8*1)+(7*9)+(6*5)+(5*1)+(4*3)+(3*6)+(2*5)+(1*2)=148
148 % 10 = 8
So 195136-52-8 is a valid CAS Registry Number.

195136-52-8Downstream Products

195136-52-8Relevant articles and documents

Fluorinated xanthene derivatives

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, (2008/06/13)

The family of dyes of the invention are fluoresceins and rhodols that are directly substituted on one or more aromatic carbons by fluorine. These fluorine-substituted fluorescent dyes possess greater photostability and have lower sensitivity to pH changes in the physiological range of 6-8 than do non-fluorinated dyes, exhibit less quenching when conjugated to a substance, and possess additional advantages. The dyes of the invention are useful as detectable tracers and for preparing conjugates of organic and inorganic substances.

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