Synthesis and antiarrhythmic activity of α-[(Diarylmethoxy)methyl]-1-piperidineethanols
A series of α-[(diarylmethoxy)methyl]-1-piperidineethanols was evaluated for antiarrhythmic activity in the coronary artery ligated dog model. Structure-activity relationship studies indicated that the 2,6-dimethylpiperidine group afforded the best antiar