- Synthetic Studies toward Bazzanin K: Regioselective and Chemoselective Three-Component Suzuki Coupling
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The terphenyl substructure of the chiral cyclophane natural product bazzanin K was constructed. The key step involved sequential Suzuki couplings of a nonsymmetric dibromobenzene, which can be performed as a two-step process or as a one-pot three-componen
- Ju, Xuan,Allen, Marshall,Zhao, Peng,Salvo, Patrick,Dyer, Frank B.,Beaudry, Christopher M.
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- Preparation of tetrazole-fused π-conjugated molecules and their fluorescence behavior
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New tetrazole-fused π-conjugated molecules were prepared from dibromobenzonitriles by repeated regioselective Sonogashira-Hagihara cross-coupling with acetylenes and intramolecular nucleophilic cyclizations. The conjugated tetracyclic compounds exhibited fluorescence with lifetimes of nanosecond order. From TD-DFT calculations, excited state wavefunctions of compounds indicated that the HOMO-1→LUMO and HOMO→LUMO+1 mainly became the first excited state (S0→S1) to contribute significantly to light emission.
- Hata, Takeshi,Hayashi, Yoshiki,Hasegawa, Yuki,Iwai, Masaaki,Ishii,, Ayumi,Hasegawa, Miki,Shigeta, Masayuki,Urabe, Hirokazu
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supporting information
p. 662 - 665
(2019/07/12)
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- Enantioselective Synthesis of the Unsaturated Fragment of Callyspongiolide
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A synthesis of the unsaturated side chain of callyspongiolide has been accomplished from two chiral building blocks prepared by catalytic asymmetric procedures applied on simple starting materials. The synthesis of the chiral benzylic alcohol was based on
- Matou?ová, Eli?ka,Koukal, Petr,Formánek, Bed?ich,Kotora, Martin
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supporting information
p. 5656 - 5659
(2016/11/17)
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- TRICYCLIC BENZOXABOROLE COMPOUNDS AND USES THEREOF
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Compounds of Formula II wherein X is selected from chloro, fluoro, bromo and iodo, R1 and R2 are each independently selected from H, -CH3, -CH2CH3, -CH2CH2CH3, or -CH(CH3)2
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Paragraph 00121-00122
(2015/02/25)
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- BORON-CONTAINING SMALL MOLECULES
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This invention relates to, among other items, benzoxaborole compounds and their use for treating bacterial infections.
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Page/Page column 76
(2012/03/27)
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- From central to axial to central chirality: Enantioselective construction of the trans-4,5,9,10-tetrahydroxy-9,10-dihydrophenanthrene system
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Enantioselective synthesis of the core trans-4,5,9,10-tetrahydroxy-9,10- dihydrophenanthrene parent system of the antibiotics benanimicin, pradimicin and FD 594 has been accomplished. The synthesis employs a chiral tether approach and makes use of efficient central to axial to central chirality transfer. Key to success was an "imine-directed" atropdiastereoselective Ullmann coupling under mild reaction conditions. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.
- Stavrakov, Georgi,Keller, Manfred,Breit, Bernhard
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p. 5726 - 5733
(2008/09/17)
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- Unforeseen formation of 2-bromo-3-hydroxybenzaldehyde by bromination of 3-hydroxybenzaldehyde
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Contrary to literature reports, bromination of 3-hydroxybenzaldehyde can afford both 2-bromo-5-hydroxybenzaldehyde and 2-bromo-3-hydroxybenzaldehyde, but 4-bromo-3-hydroxybenzaldehyde was not detected. 2-Bromo-3-hydroxybenzaldehyde was converted into 2-(benzyloxy)-1-bromo-5-methoxy-7-methylnaphthalene. X-ray crystallographic analysis supports the identity of 2-bromo-3- hydroxybenzaldehyde.
- Van Otterlo, Willem A. L.,Michael, Joseph P.,Fernandes, Manuel A.,De Koning, Charles B.
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p. 5091 - 5094
(2007/10/03)
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