- Primulin derivative as well as synthesis method and application of primulin derivative
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The invention discloses a primulin derivative with antibacterial activity shown as the structural general formula (I), wherein R is selected from C2-C20 alkyls. The primulin derivative is prepared from raw materials including m-dihydroxybenzene and a fatty acid derivative by the steps: carrying out Friedel-Crafts acylation and methylation to synthesize a paeonol derivative, and carrying out oxidization after carrying out carbonyl reduction. The primulin derivative has good antibacterial activity and can be used as a potential antibacterial agent.
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Paragraph 0021
(2018/01/11)
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- AMINOALKYL PHENOL ETHER INHIBITORS OF INFLUENZA A VIRUS
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The present invention is directed to the discovery of novel nonpeptidic small molecules that function as inhibitors of the influenza virus infection. In particular, the present invention is directed to the discovery of anti-influenza entry inhibitors with
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Page/Page column 34
(2013/06/05)
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- Dehydrative C-H alkylation and alkenylation of phenols with alcohols: Expedient synthesis for substituted phenols and benzofurans
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A well-defined cationic Ru-H complex catalyzes the dehydrative C-H alkylation reaction of phenols with alcohols to form ortho-substituted phenol products. Benzofuran derivatives are efficiently synthesized from the dehydrative C-H alkenylation and annulation reaction of phenols with 1,2-diols. The catalytic C-H coupling method employs cheaply available phenols and alcohols, exhibits a broad substrate scope, tolerates carbonyl and amine functional groups, and liberates water as the only byproduct.
- Lee, Dong-Hwan,Kwon, Ki-Hyeok,Yi, Chae S.
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supporting information; experimental part
p. 7325 - 7328
(2012/06/16)
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- INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME
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The present invention provides compounds of formula (4), and their pharmaceutically acceptable salts and solvates, which are useful as inhibitors of the Hepatitis C virus (HCV) polymerase enzyme and are also useful for the treatment of HCV infections in HCV-infected mammals. The present invention also provides pharmaceutical compositions comprising compounds of formula (4), their pharmaceutically acceptable salts and solvates. Furthermore, the present invention provides intermediate compounds and methods useful in the preparation of compounds of formula (4).
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Page/Page column 154
(2008/06/13)
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- Substituted 6-phenyl-pyridin-2-ylamines: Selective and potent inhibitors of neuronal nitric oxide synthase
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The synthesis and nNOS and eNOS activity of 6-(4-(dimethylaminoalkyl)-/6- (4-(dimethylaminoalkoxy)-5-ethyl-2-methoxyphenyl)-pyridin-2-ylamines and 6-(4-(dimethylaminoalkyl)-/6-(4-(dimethylaminoalkoxy)-2,5-dimethoxyphenyl) -pyridin-2-ylamines 1-8 are described. These compounds are potent inhibitors of the human nNOS isoform.
- Nason, Deane M.,Heck, Steven D.,Bodenstein, Mathew S.,Lowe III, John A.,Nelson, Robert B.,Liston, Dane R.,Nolan, Charles E.,Lanyon, Lorraine F.,Ward, Karen M.,Volkmann, Robert A.
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p. 4511 - 4514
(2007/10/03)
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- 2-amino-6-(2,4,5-substituted-phenyl)-pyridines
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The invention provides compounds of formula VI and the pharmaceutically acceptable salts thereof, wherein R1, R2, R3, and R4 are as defined, to pharmaceutical compositions containing such compounds and to the use of such compounds in the treatment and prevention of central nervous system and other disorders. The invention also provides methods for inhibiting neurological damage caused by impairment of glucose and/or oxygen to the brain in a mammal, which method comprises administering to the mammal a NOS inhibitor. In one embodiment, the NOS inhibitor is administered to the mammal prior to surgery, for example prior to cardiac surgery, angioplasty, or angiography.
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