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196965-14-7

SB 221284 is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 196965-14-7 Structure

  • Basic information

    1. Product Name: SB 221284
    2. Synonyms: 5-(METHYLTHIO)-1-(3-PYRIDYLCARBAMOYL)-6-(TRIFLUOROMETHYL)INDOLINE;2,3-DIHYDRO-5-(METHYLTHIO)-N-3-PYRIDINYL-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE;SB 221284
    3. CAS NO:196965-14-7
    4. Molecular Formula: C16H14F3N3OS
    5. Molecular Weight: 353.36
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 196965-14-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 536.2°C at 760 mmHg
    3. Flash Point: 278.1°C
    4. Appearance: white/solid
    5. Density: 1.43g/cm3
    6. Vapor Pressure: 1.43E-11mmHg at 25°C
    7. Refractive Index: 1.621
    8. Storage Temp.: Store at +4°C
    9. Solubility: DMSO: ~14 mg/mL, soluble
    10. CAS DataBase Reference: SB 221284(CAS DataBase Reference)
    11. NIST Chemistry Reference: SB 221284(196965-14-7)
    12. EPA Substance Registry System: SB 221284(196965-14-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 196965-14-7(Hazardous Substances Data)

196965-14-7 Usage

Uses

SB 221284 is a potent, selective SR-2C/SR-2B antagonist.

Biological Activity

Potent, selective 5-HT 2C/2B receptor antagonist. pK i values are 6.4, 7.9 and 8.6 for 5-HT 2A , 2B and 2C receptors respectively. Centrally active upon systemic administration in vivo .

Check Digit Verification of cas no

The CAS Registry Mumber 196965-14-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,6,9,6 and 5 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 196965-14:
(8*1)+(7*9)+(6*6)+(5*9)+(4*6)+(3*5)+(2*1)+(1*4)=197
197 % 10 = 7
So 196965-14-7 is a valid CAS Registry Number.
InChI:InChI=1/C16H14F3N3OS/c1-24-14-7-10-4-6-22(13(10)8-12(14)16(17,18)19)15(23)21-11-3-2-5-20-9-11/h2-3,5,7-9H,4,6H2,1H3,(H,21,23)

196965-14-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-methylsulfanyl-N-pyridin-3-yl-6-(trifluoromethyl)-2,3-dihydroindole-1-carboxamide

1.2 Other means of identification

Product number -
Other names 5-(Methylthio)-1-(3-pyridylcarbamoyl)-6-(trifluoromethyl)indoline

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:196965-14-7 SDS

196965-14-7Downstream Products

196965-14-7Relevant articles and documents

Novel and selective 5-HT(2C/2B) receptor antagonists as potential anxiolytic agents: Synthesis, quantitative structure - Activity relationships, and molecular modeling of substituted 1-(3- pyridylcarbamoyl)indolines

Bromidge, Steven M.,Dabbs, Steven,Davies, David T.,Duckworth, D. Malcolm,Forbes, Ian T.,Ham, Peter,Jones, Graham E.,King, Frank D.,Saunders, Damian V.,Starr, Susannah,Thewlis, Kevin M.,Wyman, Paul A.,Blaney, Frank E.,Naylor, Christopher B.,Bailey, Fiona,Blackburn, Thomas P.,Holland, Vicky,Kennett, Guy A.,Riley, Graham J.,Wood, Martyn D.

, p. 1598 - 1612 (2007/10/03)

The synthesis, biological activity, and molecular modeling of a novel series of substituted 1-(3-pyridylcarbamoyl)indolines are reported. These compounds are isosteres of the previously published indole urea 1 (SB- 206553) and illustrate the use of aromatic disubstitution as a replacement for fused five-membered rings in the context of 5-HT(2C/2B) receptor antagonists. By targeting a region of space previously identified as sterically allowed at the 5-HT(2C) receptor but disallowed at the 5-HT(2A) receptor, we have identified a number of compounds which are the most potent and selective 5-HT(2C/2B) receptor antagonists yet reported. 46 (SB-221284) was selected on the basis of its overall biological profile for further evaluation as a novel, potential nonsedating anxiolytic agent. A CoMFA analysis of these compounds produced a model with good predictive value and in addition good qualitative agreement with both our 5-HT(2C) receptor model and our proposed binding mode for this class of ligands within that model.

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