19716-66-6

Basic information

• Product Name: Pseudopalmatine
• Synonyms: Pseudopalmatine;2,3,10,11-Tetramethoxy-5,6-dihydrodibenzo[a,g]quinolizinium;5,6-Dihydro-2,3,10,11-tetramethoxydibenzo[a,g]quinolizinium;5,6-Dihydro-8-desmethylcoralyne;5,6-Dihydro-8-demethylcoralyne
• CAS NO: 19716-66-6
• Molecular Formula: C21H22NO4+
• Molecular Weight: 352.40368
• Mol File: 19716-66-6.mol

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: g/cm³
• CAS DataBase Reference: Pseudopalmatine(CAS DataBase Reference)
• NIST Chemistry Reference: Pseudopalmatine(19716-66-6)
• EPA Substance Registry System: Pseudopalmatine(19716-66-6)

Safety Data

• Hazardous Substances Data: 19716-66-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Pseudopalmatine is used as an analgesic agent for its pain-relieving properties, offering a natural alternative to synthetic pain medications.
Pseudopalmatine is used as an anti-inflammatory agent for its ability to reduce inflammation, which can be beneficial in treating conditions characterized by swelling and discomfort.
Used in Neuroprotection:
Pseudopalmatine is used as a neuroprotective agent to safeguard the nervous system from damage, potentially slowing the progression of neurodegenerative diseases.
Used in Addiction Treatment:
Pseudopalmatine is used as a therapeutic agent in addiction treatment, leveraging its interaction with brain receptors to help manage withdrawal symptoms and cravings.
Used in Natural Remedies:
Pseudopalmatine is used as a component in natural remedies for various ailments, capitalizing on its broad spectrum of pharmacological activities to support overall health and well-being.

InChI:InChI=1/C21H22NO4/c1-23-18-8-13-5-6-22-12-15-10-20(25-3)19(24-2)9-14(15)7-17(22)16(13)11-21(18)26-4/h7-12H,5-6H2,1-4H3/q+1

Upstream product

• 19716-59-7 8-oxypalmatine 
• 53811-50-0 6-bromo-2,3-dimethoxybenzaldehyde 
• 1745-07-9 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 26067-60-7 2,3,9,10-tetramethoxy-5,8-dihydro-6H-isoquinolino[3,2-α]isoquinoline 
• 523-02-4 2,3,10,11-tetramethoxy-5,6,7,8,13,13a-hexahydroisoquinolino[3,2-a]isoquinoline 
• 6429-04-5 1,2,3,4-tetrahydro-1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride 
• 151-50-8 potassium cyanide 
• 75821-47-5 (+/-)-trans-xylopinine N-oxide 

Relevant articles and documents

A General, Concise Strategy that Enables Collective Total Syntheses of over 50 Protoberberine and Five Aporhoeadane Alkaloids within Four to Eight Steps

A concise, catalytic, and general strategy that allowed efficient total syntheses of 22 natural 13-methylprotoberberines within four steps for each molecule is reported. This synthesis represents the most efficient and shortest route to date, featuring three catalytic processes: CuI-catalyzed redox-A3 reaction, Pd-catalyzed reductive carbocyclization, and PtO2-catalyzed hydrogenation. Importantly, this new strategy to the tetracyclic framework has also been applied to the collective concise syntheses of >30 natural protoberberines (without 13-methyl group) and five aporhoeadane alkaloids.

The Polonovski-Potier reaction of berbine N-oxides. Synthesis of 8-hydroxymethyl and 8-methylberbines

The Polonovski-Potier reaction of trans and cis berbines N-oxides was studied. The 8-cyano derivative obtained from trans N-oxides were used to synthesize 8-hydroxymethyl and 8-methyl berbines. This procedure was applied to the stereocontroled synthesis of (8R, 14S)-(-)-8-methylcanadine from (14S)-(-)-canadine. (C) 2000 Elsevier Science Ltd.