197247-92-0Relevant articles and documents
On the stereoselectivity of asymmetric strecker synthesis in a cyclohexane system: Synthesis of optically active cis- and trans-1-amino-2- hydroxycyclohexane-1-carboxylic acids
Shinada, Tetsuro,Kawakami, Tadashi,Sakai, Hiroshi,Matsuda, Hiromi,Umezawa, Taiki,Kawasaki, Masaki,Namba, Kosuke,Ohfune, Yasufumi
, p. 768 - 774 (2008/02/01)
Stereoselective synthesis of both optically active cis- and trans-1-amino-2-hydroxycyclohexane-1-carboxylic acids (Ahhs) 1a and 1b was accomplished by an asymmetric version of the Strecker synthesis. Stereochemical aspects of their chiral induction proces
Novel and efficient transformation of α-amino nitrile to α-imino and α-amide nitriles in asymmetric Strecker synthesis
Namba, Kosuke,Kawasaki, Masanori,Takada, Ichinori,Iwama, Seiji,Izumida, Masashi,Shinada, Tetsuro,Ohfune, Yasufumi
, p. 3733 - 3736 (2007/10/03)
Oxidation of α-amino nitrile 4 with ozone gave rise to a mixture of α-imino nitrile 5 and a novel fragmentation product of 6 in one-step. The mixture was converted to a variety of α-substituted α-amino acids 7 in high yields, which enabled the asymmetric transferring Strecker synthesis to be a widely useful method.
1-amino-2-hydroxycycloalkanecarboxylic acid derivatives
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, (2008/06/13)
The invention is directed to optically active 1-amino-hydroxycycloalkanecarboxylic acid compounds represented by the formula: STR1 wherein n is 0, 1, 2, 3, or 4; methods of their synthesis; and their use as compounds to fix the confirmation of a peptide o
Carbocyclic α-amino acids: Asymmetric synthesis of all four 1-amino-2- hydroxycyclohexanecarboxylic acids
Pai Fondekar, Kamalesh,Volk, Franz-J.,Frahm, August W.
, p. 727 - 735 (2007/10/03)
Starting from racemic 2-methoxycyclohexanone and (S)- or (R)-1- phenylethylamine, respectively, the four stereoisomers of 1-amino-2- hydroxycyclohexanecarboxylic acid are obtained via an asymmetric Strecker synthesis with ee values ranging from 87 to 98%.
