Diversity-oriented synthesis of pyrazoles derivatives from flavones and isoflavones leads to the discovery of promising reversal agents of fluconazole resistance in Candida albicans
Diversity-oriented synthesis of derivatives of natural products is an important approach for the discovery of novel drugs. In this paper, a series of novel 3,4-diaryl-1H-pyrazoles and 3,5-diaryl-1H-pyrazoles derivatives were synthesized through the one-po
The syntheses of 3-o-hydroxyphenyl-1,5-diphenylpyrazoles (III) and 1,3-diphenyl-5-o-hydroxyphenylpyrazoles (V) by the oxidation of corresponding pyrazolines (II) with manganese dioxide and by the reaction of phenylhydrazine with 2'-hydroxychalcone dibromi
Sharma, T. C.,Pawar, S. R.,Reddy, N. J.
p. 159 - 162
(2007/10/02)
The Preparation of 5-Phenacylisoxazoles and 5-Hydroxyphenylisoxazoles and -pyrazoles by the Condensation of C(α)-Dianions with Ethyl Benzoylacetate and Methyl Salicylate
C(α),O-Dilithiooximes and C(α),N-Dilithiophenylhydrazones were prepared in an excess of lithium diisopropylamide (LDA).The former was condensed with ethyl benzoylacetate and methyl salicylate, and the latter condensed with methyl salicylate.The resulting precyclization intermediates were than treated with aqueous acid, which was followed by cyclodehydration to give phenacylisoxazoles and hydroxyphenylisoxazoles and -pyrazoles.
Livingston, Melanie J.,Chick, MarLisa F.,Shealy, Ernest O.,Beam, Charles F.
p. 215 - 217
(2007/10/02)
More Articles about upstream products of 19726-11-5