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METHIOTHEPIN MALEATE is a maleate salt derived from the reaction of methiothepin with one equivalent of maleic acid. It is a potent 5-HT2 antagonist with additional activity as a 5-HT1 antagonist, differentiating 5-HT1D sub-types. METHIOTHEPIN MALEATE also exhibits affinity for rodent 5-HT5B, 5-HT5A, 5-HT7, and 5-HT6 receptors, with pK1 values of 6.6, 7.0, 8.4, and 8.7, respectively.

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  • 19728-88-2 Structure
  • Basic information

    1. Product Name: METHIOTHEPIN MALEATE
    2. Synonyms: RO 8-6837;1-(10,11-dihydro-8-methylthiodibenzo(b,f)thiepin-10-yl)-4-methyl-piperazin;8-methylthio-10-(4-methylpiperazino)-10,11-dihydrodibenzo(b,f)thiepinmaleate;f)thiepin,10,11-dihydro-10-(4-methylpiperazino)-8-methylthio-dibenzo(hyd;f)thiepin,10,11-dihydro-8-methylthio-10-(4-methylpiperazino)-dibenzo(hyd;metitepinmaleate;1-[10,11-DIHYDRO-8-(METHYLTHIO)DIBENZO[B,F]THIEPIN-10-YL]-4-METHYLPIPERAZINE MALEATE;METHIOTHEPIN MALEATE
    3. CAS NO:19728-88-2
    4. Molecular Formula: C24H28N2O4S2
    5. Molecular Weight: 472.62
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 19728-88-2.mol
  • Chemical Properties

    1. Melting Point: 171-173°
    2. Boiling Point: 462.9°Cat760mmHg
    3. Flash Point: 233.8°C
    4. Appearance: /
    5. Density: g/cm3
    6. Vapor Pressure: 3.61E-08mmHg at 25°C
    7. Refractive Index: N/A
    8. Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
    9. Solubility: N/A
    10. CAS DataBase Reference: METHIOTHEPIN MALEATE(CAS DataBase Reference)
    11. NIST Chemistry Reference: METHIOTHEPIN MALEATE(19728-88-2)
    12. EPA Substance Registry System: METHIOTHEPIN MALEATE(19728-88-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 19728-88-2(Hazardous Substances Data)

19728-88-2 Usage

Uses

Used in Biochemical Research:
METHIOTHEPIN MALEATE is used as a biochemical tool in serotonin receptor binding studies, aiding researchers in understanding the interactions between serotonin receptors and various compounds.
Used in Pharmaceutical Industry:
METHIOTHEPIN MALEATE is used as an anticonvulsant agent, demonstrating the ability to suppress pentylenetetrazol-induced fos expression in zebrafish. This property makes it a potential candidate for the development of treatments for seizure disorders.
Used in Neurology Research:
As a 5-HT antagonist, METHIOTHEPIN MALEATE is used in the study of serotonin's role in various neurological and psychiatric conditions. Its ability to differentiate 5-HT1D sub-types and display affinity for other serotonin receptors makes it a valuable tool for investigating the complex interactions within the serotonin system.

Check Digit Verification of cas no

The CAS Registry Mumber 19728-88-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,7,2 and 8 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 19728-88:
(7*1)+(6*9)+(5*7)+(4*2)+(3*8)+(2*8)+(1*8)=152
152 % 10 = 2
So 19728-88-2 is a valid CAS Registry Number.
InChI:InChI=1/C20H24N2S2.C4H4O4/c1-21-10-12-22(13-11-21)17-14-15-6-3-4-8-18(15)24-20-16(17)7-5-9-19(20)23-2;5-3(6)1-2-4(7)8/h3-9,17H,10-14H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

19728-88-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name methiothepin maleate

1.2 Other means of identification

Product number -
Other names methiothepin hydrogen maleate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:19728-88-2 SDS

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