Synthesis of ε-N-propionyl-, ε-N-butyryl-, and ε-N-crotonyl-lysine containing histone H3 using the pyrrolysine system
Recently new lysine modifications were detected in histones and other proteins. Using the pyrrolysine amber suppression system we genetically inserted three of the new amino acids ε-N-propionyl-, ε-N-butyryl-, and ε-N-crotonyl-lysine site specifically int
Gattner, Michael J.,Vrabel, Milan,Carell, Thomas
supporting information
p. 379 - 381
(2013/02/22)
Polymeric hydrogels modified with ornithine and lysine: Sorption and release of metal cations and amino acids
A novel, convenient synthesis, using copper ions, is described for the multigram-scale preparation of acryloyl and methacryloyl ornithine and lysine without the need to use protecting groups and chromatographic purifications. Three methods of removing the
Romanski, Jan,Karbarz, Marcin,Pyrzynska, Krystyna,Jurczak, Janusz,Stojek, Zbigniew
scheme or table
p. 542 - 550
(2012/04/23)
Molecular rotations of N(α)-acyl-L-lysines at various pH values
Molecular rotations of N(α)-acyl-L-lysines were determined in water and in water containing various amounts of HCl or NaOH. The acyl groups were formyl, acetyl, propionyl, and butyryl. Each N(α)-acyl-L-lysine exhibited more negative rotation in HCl or NaOH solution than in water. The plot of molecular rotation against amount of HCl or NaOH resembled that of a D-α-amino acid even though N(α)-acyl-lysine was of L-form. The reason for this is discussed from the standpoint of steric factors. N(ε)-Acyl-L-lysines corresponding to the N(α)-acyl-L-lysines were synthesized as reference compounds. It was found that water-soluble N(ε)-acyl-L-lysines can be easily prepared by acylation of the Cu complex solution of L-lysine hydrochloride in the presence of triethylamine. The molecular rotation plots for N(ε)-acyl-L-lysines were typical of L-α-amino acids.
Soejima,Akagi,Izumiya
p. 2618 - 2620
(2007/10/02)
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