197516-48-6 Usage
Uses
Used in Chemical Synthesis:
5-Hydrazinyl-2-methylpyridine is used as a building block in the synthesis of various organic compounds. Its unique structure allows it to participate in a wide array of chemical reactions, making it a valuable component in the creation of new molecules with potential applications in different industries.
Used in Pharmaceutical Industry:
5-Hydrazinyl-2-methylpyridine is used as an intermediate in the development of pharmaceutical compounds. Its hydrazinyl functional group can be exploited to form new drug molecules with potential therapeutic properties, contributing to the advancement of medicine and healthcare.
Used in Research and Development:
5-Hydrazinyl-2-methylpyridine is used as a research compound in academic and industrial laboratories. Its reactivity and structural features make it an interesting subject for studying chemical reactions and exploring new synthetic pathways, which can lead to the discovery of novel compounds with various applications.
Used in Material Science:
5-Hydrazinyl-2-methylpyridine is used as a component in the development of new materials with specific properties. Its incorporation into polymers or other materials can result in materials with unique characteristics, such as improved stability, reactivity, or selectivity, which can be beneficial in various applications.
Used in Agrochemical Industry:
5-Hydrazinyl-2-methylpyridine is used as a precursor in the synthesis of agrochemicals, such as pesticides or herbicides. Its potential to form new molecules with bioactivity can contribute to the development of more effective and environmentally friendly agricultural products.
Check Digit Verification of cas no
The CAS Registry Mumber 197516-48-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,7,5,1 and 6 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 197516-48:
(8*1)+(7*9)+(6*7)+(5*5)+(4*1)+(3*6)+(2*4)+(1*8)=176
176 % 10 = 6
So 197516-48-6 is a valid CAS Registry Number.
InChI:InChI=1/C6H9N3/c1-5-2-3-6(9-7)4-8-5/h2-4,9H,7H2,1H3
197516-48-6Relevant articles and documents
Structure-Activity Relationships of the p38α MAP Kinase Inhibitor 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy) naphthalen-1-yl]urea (BIRB 796)
Regan, John,Capolino, Alison,Cirillo, Pier F.,Gilmore, Thomas,Graham, Anne G.,Hickey, Eugene,Kroe, Rachel R.,Madwed, Jeffrey,Moriak, Monica,Nelson, Richard,Pargellis, Christopher A.,Swinamer, Alan,Torcellini, Carol,Tsang, Michele,Moss, Neil
, p. 4676 - 4686 (2007/10/03)
We report on the structure-activity relationships (SAR) of 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy) naphthalen-1-yl]urea (BIRB 796), an inhibitor of p38α MAP kinase which has advanced into human clinical trials for the treatment of autoimmune diseases. Thermal denaturation was used to establish molecular binding affinities for this class of p38α inhibitors. The tert-butyl group remains a critical binding element by occupying a lipophilic domain in the kinase which is exposed upon rearrangement of the activation loop. An aromatic ring attached to N-2 of the pyrazole nucleus provides important π-CH 2 interactions with the kinase. The role of groups attached through an ethoxy group to the 4-position of the naphthalene and directed into the ATP-binding domain is elucidated. Pharmacophores with good hydrogen bonding potential, such as morpholine, pyridine, and imidazole, shift the melting temperature of p38α by 16-17 °C translating into Kd values of 50-100 pM. Finally, we describe several compounds that potently inhibit TNF-α production when dosed orally in mice.
