Method for synthesis and 99m C labelling of 2-alkoxyisobutylisonitrile
A new method for synthesizing 2-alkoxyisobutylisonitrile is provided in which isobutylene is used as the starting material. The haloalkoxylation of isobutylene in alcohol medium gives 2-alkoxyisobutylhalide which is then converted to 2-alkoxyisobutylamine. In the basic condition, the reaction of 2-alkoxyisobutylamine with chloroform produces 2-alkoxyisobutylisonitrile. The synthesis process contains three steps by which a higher yield is achieved. 2-Alkoxyisobutylisonitrile is labelled with technetium-99m by exchange labelling of stable tetrakis(2-alkoxyisobutylisonitrile)copper(I) complex. Tetrakis(2-alkoxyisobutylisonitrile)copper(I) complex can be prepared by the exchange of acetonitrile molecules in tetrakis(acetonitrile)copper(I) complex with isonitrile ligands.
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(2008/06/13)
Solvation and Steric Effects on Electrophilic Reactivity of Ethylenic Compounds. 3. Stereo-, Regio-, and Chemoselectivity of Alkene Bromination in Methanol
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Chretien, Jacques R.,Coudert, Jean-Daniel,Ruasse, Marie-Francoise
p. 1917 - 1921
(2007/10/02)
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