- Synthesis and protective effects of aralkyl alcoholic 2-acetamido-2-deoxy- β-d-pyranosides on hypoglycemia and serum limitation induced apoptosis in PC12 cell
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Neuroprotective agents have been in the focus of attention in the treatment of ischemic stroke. Salidroside, a phenylpropanoid glycoside isolated from Rhodiola rosea L., possessed a wide range of biological activities, especially neuroprotection. In an at
- Meng, Ying,Guo, Yibing,Ling, Yong,Zhao, Yahong,Zhang, Qi,Zhou, Xinyang,Ding, Fei,Yang, Yumin
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experimental part
p. 5577 - 5584
(2011/10/13)
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- Synthesis of hydrophobic derivatives of muramyldipeptides
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Methyl esters of the cyclohexyl-, phenethyl-, (2-naphthyl)methyl-, and 2′-(1-naphthyl)ethyl β-glycosides of N-acetylmuramyl-L-alanyl-D-isoglutamine have been synthesized. The corresponding glycosides of N-acetylglucosamine were obtained by glycosylating the alcohols with the peracetate of α-glucosaminyl chloride in the presence of HgI2, followed by deacetylation. Subsequent benzylidenation and alkylation with α-L-chloropropionic acid led to glycosylmuramic acids, the condensation of which with the dipeptide and final debenzylidenation gave the desired glycopeptides.
- Zemlyakov,Kur'yanov,Tsikalov,Aksenova,Chirva
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