A new synthetic approach for the regiospecific alkylation of the 6-position of the tropane ring system has been developed. Alkylation, desulfonylation and deprotection of tropanes 5 and 12 furnished a series of 6-endo-alkyltropan-2-one derivatives 8a-e, 1
Lomenzo, Stacey A.,Bradley, Amy L.,Zhu, Naijue,Klein, Cheryl L.,Trudell, Mark L.