Oral targeting nanoparticles based on intestinal epithelial cell apical OCTN2 transporter
The invention belongs to the field of new auxiliary materials and new dosage forms of pharmaceutic preparations, and relates to preparation of a derivative of L-carnitine as a substrate of an intestinal epithelial cell apical OCTN2 transporter and corresponding targeting nanoparticles, and application of the targeting nanoparticles as oral drug carriers in the aspect of drug delivery. Stearoyl-L carnitine is an amphipathic compound consisting L-carnitine as the substrate of the OCTN2 transporter and stearic acid, and is a targeting ligand which is good in stability and is used for constructing an OCTN2 targeting nano drug delivery system. The stearic acid can be long-chain fatty acids such as octadecanoic acid, palmitic acid and tetradecanoic acid. The structural formula of the amphipathic compound is as shown in the specification.
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Paragraph 0020-0021; 0023; 0048-0050; 0107
(2017/10/10)
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