- Homo- and Heterobimetallic Complexes Bearing NHC Ligands: Applications in α-Arylation of Amide, Suzuki–Miyaura Coupling Reactions, and Tandem Catalysis
-
A heterobimetallic IrIII/PdII complex from a dicarbene donor ligand featuring cyclometalated IrIII and PEPPSI type PdII is presented along with a homodinuclear PEPPSI type PdII complex starting from the same bis-imidazolium salt. All the PdII complexes are active precatalyst in both α-arylation and Suzuki–Miyaura coupling reactions. The heterobimetallic IrIII/PdII complex shows much higher yields in tandem C–C coupling/transfer hydrogenation reactions compared to the equimolar mixture of their mononuclear PdII and IrIII counterparts.
- Majumder, Adhir,Naskar, Rajat,Roy, Pallabi,Maity, Ramananda
-
p. 1810 - 1815
(2019/03/17)
-
- Biaryl pyridine palladacycles nitrogen heterocyclic carbene compound and its preparation and use
-
The invention discloses an aryl-pyridine cyclic Pd-N heterocyclic carbene compound. The general formula of the compound is described in the specification, wherein X is selected from Cl, Br and I, L is an N-heterocyclic carbene ligand, and Aryl is an aryl. The invention also discloses a preparation method of the compound. The preparation method comprises the following steps of: adding 2-(4-halogen atom phenyl)-pyridine, imidazolium salt, arylboronic acid, halogenated palladium and alkaline into an organic solvent, heating under the protection of gas, filtering after reaction is finished, drying by distillation, and purifying, thus the aryl-pyridine cyclic Pd-N heterocyclic carbene compound is obtained. The compound can serve as a catalyst and is used for catalyzing reaction between halogenated benzyl alcohol and arylboronic acid to synthesize aryl methyl alcohol. The preparation method has the characteristics of various substrates, mild reaction conditions, high yield, economy and high efficiency and has an important practical value.
- -
-
Paragraph 0049; 0050
(2017/01/31)
-
- Water-soluble palladacycles containing hydroxymethyl groups: Synthesis, crystal structures and use as catalysts for amination and Suzuki coupling of reactions
-
Two water-soluble monophosphine [PPh3 and 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl(Sphos)]-palladacycles containing hydroxymethyl groups 2-3 were prepared by cyclopalladation and chloride bridge-splitting reactions. The complexes were characterized by elemental analysis, ESI-MS and NMR. In addition, single-crystal X-ray analysis reveals that they have one-dimensional lamellar structures involving intermolecular hydrogen bonds and π-π interactions. The use of these palladacycles as catalysts for amination and Suzuki coupling of aryl chlorides in water was investigated. Complex 3 was found to be very efficient for these coupling reactions. Additionally, it was also successfully used in Suzuki coupling of (hydroxymethyl)phenylboronic acid for the synthesis of substituted 2-N-heterocyclic biarylmethanols.
- Han, Xin,Li, Hong-Mei,Xu, Chen,Xiao, Zhi-Qiang,Wang, Zhi-Qiang,Fu, Wei-Jun,Hao, Xin-Qi,Song, Mao-Ping
-
p. 403 - 411
(2016/04/19)
-
- Cross-Coupling of Organolithium with Ethers or Aryl Ammonium Salts by C?O or C?N Bond Cleavage
-
Various aryl-, alkenyl-, and/or alkyllithium species reacted smoothly with aryl and/or benzyl ethers with cleavage of the inert C?O bond to afford cross-coupled products, catalyzed by commercially available [Ni(cod)2] (cod=1,5-cyclooctadiene) catalysts with N-heterocyclic carbene (NHC) ligands. Furthermore, the coupling reaction between the aryllithium compounds and aryl ammonium salts proceeded under mild conditions with C?N bond cleavage in the presence of a [Pd(PPh3)2Cl2] catalyst. These methods enable selective sequential functionalizations of arenes having both C?N and C?O bonds in one pot.
- Yang, Ze-Kun,Wang, Dong-Yu,Minami, Hiroki,Ogawa, Hiroyuki,Ozaki, Takashi,Saito, Tatsuo,Miyamoto, Kazunori,Wang, Chao,Uchiyama, Masanobu
-
supporting information
p. 15693 - 15699
(2016/10/25)
-
- CARBAMATE DERIVATIVES OF LACTAM BASED N-ACYLETHANOLAMINE ACID AMIDASE (NAAA) INHIBITORS
-
Described herein are compounds and pharmaceutical compositions which inhibit N-acylethanolamine acid amidase (NAAA). Described herein are methods for synthesizing the compounds set forth herein and methods for formulating these compounds as pharmaceutical compositions which include these compounds. Also described herein are methods of inhibiting NAAA in order to sustain the levels of palmitoylethanolamide (PEA) and other N-acylethanolamines (NAE) that are substrates for NAAA, in conditions characterized by reduced concentrations of NAE. Also, described here are methods of treating and ameliorating pain, inflammation, inflammatory diseases, and other disorders in which modulation of fatty acid ethanolamides is clinically or therapeutically relevant or in which decreased levels of NAE are associated with the disorder.
- -
-
-
- N-Tosylhydrazine-mediated deoxygenative hydrogenation of aldehydes and ketones catalyzed by Pd/C
-
A mild and efficient method for the deoxygenative hydrogenation of aldehydes and ketones has been developed. The reaction is mediated by N-tosylhydrazine with H2 (1 atm) as the reductant and 10% Pd/C as the catalyst.
- Zhou, Lei,Liu, Zhenxing,Liu, Yizhou,Zhang, Yan,Wang, Jianbo
-
p. 6083 - 6087
(2013/07/25)
-