- New pharmaceutical combinations for NOS inhibitors
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The present invention relates to new pharmaceutical uses for compounds that exhibit activity as nitric oxide synthase (NOS) inhibitors. Specifically, it relates to the use of NOS inhibitors, particularly selective neuronal NOS (nNOS) inhibitors, alone or in combination with another active agent, in particular, either an SSRI or an NK-1 receptor antagonist, for the treatment of disorders or conditions the treatment which can be effected or facilitated by altering circadian rhythms. Examples of such disorders and conditions are blindness, obesity, seasonal affective disorder, bipolar disorder; jet lag, circadian sleep rhythms disorder, sleep deprivation, parasomnias, REM sleep disorders, hypersomnia, sleep-wake cycle disorders, narcolepsy and sleep disorders associated with shift work or irregular work schedules; nocturnal enuresis, and restless-legs syndrome.
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- PHARMACEUTICAL USES FOR NOS INHIBITORS
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The present invention relates to new pharmaceutical uses for compounds that exhibit activity as nitric oxide synthase (NOS) inhibitors. Specifically, it relates to the use of NOS inhibitors, particularly selective neuronal NOS (N-NOS) inhibitors: (a) alon
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- 6-phenyl-pyridin-2-ylamine derivatives
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The present invention relates to certain 6-phenyl-pyridin-2-ylamine derivatives that exhibit activity as nitric oxide synthase (NOS) inhibitors, to pharmaceutical compositions containing them and to their use in the treatment and prevention of central nervous system disorders.
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- A new class of selective and potent inhibitors of neuronal nitric oxide synthase
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The synthesis and SAR of a series of 6-(4-(substituted)phenyl)-2-aminopyridines as inhibitors of nitric oxide synthase are described. Compound 3a from this series shows potent and selective inhibition of the human nNOS isoform, with pharmacokinetics sufficient to provide in vivo inhibition of nNOS activity.
- Lowe III, John A.,Qian, Weimin,Volkmann, Robert A.,Heck, Steven,Nowakowski, Jolanta,Nelson, Robert,Nolan, Charles,Liston, Dane,Ward, Karen,Zorn, Stevin,Johnson, Celeste,Vanase, Michelle,Faraci, W. Stephen,Verdries, Kimberly A.,Baxter, James,Doran, Shawn,Sanders, Martin,Ashton, Mike,Whittle, Peter,Stefaniak, Mark
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p. 2569 - 2572
(2007/10/03)
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