198341-10-5

Basic information

• Product Name: 2,3-DIHYDRO-2,2-DIMETHYL-6-FLUORO-1H-INDEN-1-ONE
• Synonyms: 2,3-DIHYDRO-2,2-DIMETHYL-6-FLUORO-1H-INDEN-1-ONE
• CAS NO: 198341-10-5
• Molecular Formula: C11H11FO
• Molecular Weight: 178.2
• Mol File: 198341-10-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,3-DIHYDRO-2,2-DIMETHYL-6-FLUORO-1H-INDEN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DIHYDRO-2,2-DIMETHYL-6-FLUORO-1H-INDEN-1-ONE(198341-10-5)
• EPA Substance Registry System: 2,3-DIHYDRO-2,2-DIMETHYL-6-FLUORO-1H-INDEN-1-ONE(198341-10-5)

Safety Data

• Hazardous Substances Data: 198341-10-5(Hazardous Substances Data)

Upstream product

• 1481-32-9 6-fluoroindan-1-one 
• 74-88-4 methyl iodide 

Relevant articles and documents

Enantioselective Synthesis of Indanes with a Quaternary Stereocenter via Diastereoselective C(sp3)-H Functionalization

A practical synthesis of enantioenriched indane derivatives with quaternary stereocenters was developed via sequential enantioselective reduction and C-H functionalization. Good to excellent enantioselectivity could be achieved by either the CuH-catalyzed asymmetric reduction or the Corey-Bakshi-Shibata (CBS) reduction of indanone derivatives. The subsequent diastereospecific and regioselective rhodium-catalyzed silylation of the methyl C-H bond led to indane derivatives with quaternary centers. This strategy was further applied in syntheses of (nor)illudalane and botryane sesquiterpenoids.

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