198782-59-1Relevant articles and documents
An Approach to Modify 14-Membered Lactone Macrolide Antibiotic Scaffolds
Janas, Anna,Pyta, Krystian,Gdaniec, Maria,Przybylski, Piotr
supporting information, p. 3758 - 3761 (2022/02/07)
A ketolide derivative with (12R)-configuration was obtained via a novel ketene acetal in acidic conditions. The structure of this atypical β-keto ketene acetal intermediate within the macrocyclic system has been determined by NMR and X-ray methods. The use of basic conditions at an elevated temperature yielded new, doubly α,β-unsaturated ketone macrolide derivatives with (4E)-configuration as two conformational isomers of folded-in or folded-out conformations.
PROCESS FOR THE PRODUCTION OF TELITHROMYCIN
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Page/Page column 10; 15-16, (2009/05/28)
The present invention relates to a process for the preparation of erythromysin derivatives, in particular telithromycin of formula (I) and its pharmaceutically acceptable salts, providing the isolated intermediates in crystalline form of superior stability and purity.