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(1S,4S)-2-(4-CHLOROPHENYL)-2,5-DIAZABICYCLO[2.2.1]HEPTANE HBR, also known as vesamicol, is a bicyclic compound featuring a 4-chlorophenyl group attached. It is widely recognized for its high affinity towards the vesicular acetylcholine transporter (VAChT), making it a prominent figure in the field of neuroscience research.
Used in Neuroscience Research:
(1S,4S)-2-(4-CHLOROPHENYL)-2,5-DIAZABICYCLO[2.2.1]HEPTANE HBR serves as a radiotracer for visualizing cholinergic nerve terminals in both the central and peripheral nervous systems. Its application is particularly valuable in the study of neurodegenerative diseases such as Alzheimer's and Parkinson's, where understanding the role of acetylcholine in synaptic transmission and neurotransmitter uptake is crucial.
Used in Positron Emission Tomography (PET) Imaging Studies:
In the realm of medical imaging, (1S,4S)-2-(4-CHLOROPHENYL)-2,5-DIAZABICYCLO[2.2.1]HEPTANE HBR plays a significant role as it enables the visualization and quantification of VAChT levels in living organisms. This capability is instrumental in advancing our knowledge of neurological conditions and potential therapeutic interventions.

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  • 198988-88-4 Structure
  • Basic information

    1. Product Name: (1S,4S)-2-(4-CHLOROPHENYL)-2,5-DIAZABICYCLO[2.2.1]HEPTANE HBR
    2. Synonyms: (1S,4S)-2-(4-CHLOROPHENYL)-2,5-DIAZABICYCLO[2.2.1]HEPTANE HBR
    3. CAS NO:198988-88-4
    4. Molecular Formula: C11H14BrClN2
    5. Molecular Weight: 289.6
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 198988-88-4.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 356.5±27.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.238±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 9.58±0.20(Predicted)
    10. CAS DataBase Reference: (1S,4S)-2-(4-CHLOROPHENYL)-2,5-DIAZABICYCLO[2.2.1]HEPTANE HBR(CAS DataBase Reference)
    11. NIST Chemistry Reference: (1S,4S)-2-(4-CHLOROPHENYL)-2,5-DIAZABICYCLO[2.2.1]HEPTANE HBR(198988-88-4)
    12. EPA Substance Registry System: (1S,4S)-2-(4-CHLOROPHENYL)-2,5-DIAZABICYCLO[2.2.1]HEPTANE HBR(198988-88-4)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 198988-88-4(Hazardous Substances Data)

198988-88-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 198988-88-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,8,9,8 and 8 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 198988-88:
(8*1)+(7*9)+(6*8)+(5*9)+(4*8)+(3*8)+(2*8)+(1*8)=244
244 % 10 = 4
So 198988-88-4 is a valid CAS Registry Number.

198988-88-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name (1S,4S)-2-(4-CHLOROPHENYL)-2,5-DIAZABICYCLO[2.2.1]HEPTANE HBR

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:198988-88-4 SDS

198988-88-4Upstream product

198988-88-4Relevant articles and documents

Selective deprotection of methanesulfonamides to amines

Naito, Hiroyuki,Hata, Takeshi,Urabe, Hirokazu

experimental part, p. 1228 - 1230 (2010/06/13)

"Chemical Equation Presented" Methanesulfonamldes were deprotected to their parent amines via deprotonation and oxygenation with O 2 (g), even in the presence of other traditional sulfonamides.

BENZAZEPINE DERIVATIVES, MEDICAMENTS CONTAINING THE SAME AND THEIR USE TO PREPARE MEDICAMENTS

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, (2008/06/13)

New derivatives of benzazepine, particularly of benzofuro[3a,3,2,ef][2]benzazepin of the general formula (I) and new compounds of the general formula (III) Drugs, containing compounds of formulas (I) and/or (III), which can be used successfully for the tr

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