199191-11-2

Basic information

• Product Name: [(2S)-3-benzyloxy-1,1,2-trimethyl-propoxy]-tert-butyl-dimethyl-silane
• CAS NO: 199191-11-2
• Molecular Formula: C₁₉H₃₄O₂Si
• Molecular Weight: 322.5576
• Mol File: 199191-11-2.mol

Chemical Properties

• Boiling Point: 356.039°C at 760 mmHg
• Flash Point: 141.711°C
• Density: 0.914g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.472
• CAS DataBase Reference: [(2S)-3-benzyloxy-1,1,2-trimethyl-propoxy]-tert-butyl-dimethyl-silane(CAS DataBase Reference)
• NIST Chemistry Reference: [(2S)-3-benzyloxy-1,1,2-trimethyl-propoxy]-tert-butyl-dimethyl-silane(199191-11-2)
• EPA Substance Registry System: [(2S)-3-benzyloxy-1,1,2-trimethyl-propoxy]-tert-butyl-dimethyl-silane(199191-11-2)

Safety Data

• Hazardous Substances Data: 199191-11-2(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
[(2S)-3-benzyloxy-1,1,2-trimethyl-propoxy]-tert-butyl-dimethyl-silane is used as a key intermediate for the synthesis of various organic molecules and materials. Its unique structure allows for specific reactivity patterns that are beneficial in creating complex organic compounds.
Used as a Protecting Group in Organic Synthesis:
[(2S)-3-benzyloxy-1,1,2-trimethyl-propoxy]-tert-butyl-dimethyl-silane serves as an effective protecting group for alcohols and other functional groups during organic synthesis. Its role is crucial in preventing unwanted side reactions, ensuring the selective protection of sensitive functional groups until they are needed in the reaction sequence.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, [(2S)-3-benzyloxy-1,1,2-trimethyl-propoxy]-tert-butyl-dimethyl-silane is used as a building block for the development of new drugs. Its unique properties facilitate the creation of complex molecular structures that can target specific biological pathways.
Used in Agrochemicals:
[(2S)-3-benzyloxy-1,1,2-trimethyl-propoxy]-tert-butyl-dimethyl-silane is also utilized in the agrochemical industry for the synthesis of various chemical products, such as pesticides and fertilizers, that require intricate organic frameworks for their mode of action.
Used in Organosilicon Chemistry:
[(2S)-3-benzyloxy-1,1,2-trimethyl-propoxy]-tert-butyl-dimethyl-silane plays a significant role in organosilicon chemistry, where it is employed in the development of new materials with specific properties, such as improved thermal stability or unique electronic characteristics.

Upstream product

• 69739-34-0 t-butyldimethylsiyl triflate 
• 199191-10-1 4-benzyloxy-2,3-dimethylbutan-2-ol 
• 59965-24-1 (+/-)-methyl 2-methyl-3-(phenylmethoxy)propanoate 

Downstream Products

• 144436-47-5 3-(tert-Butyl-dimethyl-silanyloxy)-2,3-dimethyl-butan-1-ol 
• 199191-21-4 N-[3-(tert-butyldimethylsiloxy)-2,3-dimethylbutylidene]benzylamine N-oxide 

Relevant articles and documents

Influence of a 2-fluoro substituent on diastereoselectivity in the 1,3-dipolar cycloadditions of nitrones

It is clear that the role of 1,2-asymmetric induction on the 1,3-dipolar cycloaddition of nitrones is influenced by the presence of a fluorine atom at the C-2 position. 2-Fluoro nitrones, synthesized by three different methods, have been subjected to the intermolecular 1,3-dipolar cycloaddition with ethyl vinyl ether. The stereostructures of isoxazolidines formed were determined by their conversion into 2,7-dioxa-6-azabicyclo[3.2.1]octanes. The diastereoselectivity of 2-fluoro nitrones was the reverse of that of the corresponding 2-hydro nitrones. This fact supports that the conformation with relief from the dipole repulsion between the fluorine atom and the oxygen atom of the nitrone is a preferred one for 2-fluoro nitrones, while the corresponding 2-hydro nitrones adopt the conformation with the least 1,3-allylic strain.