Synthesis of 2-aroylmethylquinolin-4-ones via the addition reaction of ortho-nitrobenzoylketene to 1-aryl-l-trimethylsilyloxyethylenes
Catalytic hydrogenation of 1-aryl-5-(2-nitrophenyl)pentane-1,3,5-triones A over 10% Pd-C caused selective reduction of the nitro group with concomitant cyclization to give 2-aroylmethylquinolin-4-ones B. This provides a simple method of quinolin-4-one synthesis.
Toda, Jun,Saitoh, Toshiaki,Sano, Takehiro
p. 1937 - 1944
(2007/10/03)
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