Convenient synthesis of pyrrole- and indolecarboxylic acid tert-butylesters
The tert-butylesters of pyrrole- and indolecarboxylic acids are readily accessed by reacting the appropriate carboxylic acids with N,N-dimethylformamide di-tert-butyl acetal.
CARBOXYL SUBSTITUTED INDOLES FOR USE AS PPAR ALPHA MODULATORS
There is provided according to the invention novel compounds of formula (I) or pharmaceutically acceptable salts or solvates thereof wherein one of R1 and R2 is H and the other is COOH. The compounds are useful as PPAR modulators.
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Page/Page column 64
(2009/12/28)
NOVEL HETEROARYL-SUBSTITUTED ACETONE DERIVATIVES AS INHIBITORS OF PHOSPHOLIPASE A2
The invention relates to novel heteroaryl-substituted acetone derivatives, which inhibit the enzyme phospholipase A2, to pharmaceutical agents that contain said compounds and to a method for producing said compounds.
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(2008/06/13)
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