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199593-08-3

N4-ACETYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLCYTIDINE is a chemical compound that is a modified form of cytidine, a nucleoside. It features an acetyl group at the N4 position, a dimethoxytrityl group at the 5' position, and a methyl group at the 2'-O position of the ribose sugar. These modifications enhance its utility in the synthesis of nucleic acids and as a component in the creation of various nucleotide analogs, making it a valuable asset in molecular biology and pharmaceutical research.

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  • N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxy-3-methoxyoxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide

    Cas No: 199593-08-3

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  • 199593-08-3 Structure

  • Basic information

    1. Product Name: N4-ACETYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLCYTIDINE
    2. Synonyms: N4-ACETYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLCYTIDINE;N4-Acetyl-5'-O-DMT-2'-O-methyl-D-cytidine;DMT-2'-OMe-Ac-C;N4-Acetyl-5'-O-DMT-2'-O-methylcytidine;N-(1-((2R,3R,4R,5R)-5-((bis(4-Methoxyphenyl)(phenyl)Methoxy)Methyl)-4-hydroxy-3-Methoxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyriMidin-4-yl)acetaMide;N-Acetyl-5'-O-(4,4'-diMethoxytrityl)-2'-O-Methylcytidine;N-Acetyl-5'-O-[bis(4-methoxyphenyl)-phenylmethyl]-2'-O-methyl-cytidine;5'-O-DMT-N4-Acetyl-2'-O-Methyl-cytidine
    3. CAS NO:199593-08-3
    4. Molecular Formula: C33H35N3O8
    5. Molecular Weight: 601.6463
    6. EINECS: 2017-001-1
    7. Product Categories: N/A
    8. Mol File: 199593-08-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: White to Pale Yellow/Powder
    5. Density: 1.28±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. PKA: 10.19±0.20(Predicted)
    10. CAS DataBase Reference: N4-ACETYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLCYTIDINE(CAS DataBase Reference)
    11. NIST Chemistry Reference: N4-ACETYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLCYTIDINE(199593-08-3)
    12. EPA Substance Registry System: N4-ACETYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLCYTIDINE(199593-08-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 199593-08-3(Hazardous Substances Data)

199593-08-3 Usage

Uses

Used in Molecular Biology Research:
N4-ACETYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLCYTIDINE is used as a building block for the synthesis of nucleic acids due to its modified structure, which facilitates the creation of specific nucleotide analogs for various research applications.
Used in Pharmaceutical Research:
In the pharmaceutical industry, N4-ACETYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLCYTIDINE is used as a key component in the development of novel drugs, particularly those targeting nucleic acid-based therapies. Its unique properties allow for the exploration of new drug candidates with potential therapeutic benefits.
Used in Nucleic Acid Synthesis:
N4-ACETYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLCYTIDINE is utilized as a modified nucleoside in the synthesis of custom or specialized nucleic acid sequences, which can be employed in various biological assays and for the study of nucleic acid interactions.

Check Digit Verification of cas no

The CAS Registry Mumber 199593-08-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,9,5,9 and 3 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 199593-08:
(8*1)+(7*9)+(6*9)+(5*5)+(4*9)+(3*3)+(2*0)+(1*8)=203
203 % 10 = 3
So 199593-08-3 is a valid CAS Registry Number.

199593-08-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxy-3-methoxyoxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide

1.2 Other means of identification

Product number -
Other names N4-acetyl-5'-O-DMTr-2'-O-methylcytidine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:199593-08-3 SDS

199593-08-3Relevant articles and documents

Ultrafast cleavage and deprotection of oligonucleotides synthesis and use of C(Ac) derivatives

Reddy,Hanna, Naeem B.,Farooqui, Firdous

, p. 1589 - 1598 (2007/10/03)

We have investigated the use of alkylamines as fast cleavage and deprotection reagents for the solid phase synthesis of oligonucleotides and found methylamine/ammonium hydroxide (or methylamine) as an efficient reagent. The transamination side product formed with the commonly used dC(b2) has been eliminated by the use of dC(Ac) phosphoramidite. This system has successfully been used in the synthesis of oligonucleotides and oligonucleoside phosphorothioates. DMT dC(Ac) hydrogen phosphonate and DMT ribo C(Ac)-2'-OMe phosphoramidite also have been prepared and used in the synthesis of oligonucleotides.

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