199798-84-0 Usage
Uses
Used in Benign Prostatic Hyperplasia (BPH) Treatment:
Elocalcitol is used as a therapeutic agent for the treatment of BPH, as it effectively induces apoptosis in androgen-stimulated BPH cells and inhibits prostate overgrowth in rat models.
Used in Allergen-Induced Interstitial Cystitis Treatment:
Elocalcitol is used as an anti-inflammatory agent in the treatment of allergen-induced interstitial cystitis. It helps reduce the expression of IL-13 and IgE/mast cell-derived protease 1 (MMCP1), as well as decrease edema and leukocyte infiltration in the bladder wall in mouse models.
Used in Endometriosis Treatment:
Elocalcitol is used as a therapeutic agent for endometriosis, as it reduces the number of adherent endometrial stromal cells and decreases the total weight of endometrial lesions in mouse models.
Clinical Investigation:
Formulations containing Elocalcitol are currently under clinical investigation for the treatment of BPH, further exploring its potential applications and effectiveness in medical treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 199798-84-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,9,7,9 and 8 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 199798-84:
(8*1)+(7*9)+(6*9)+(5*7)+(4*9)+(3*8)+(2*8)+(1*4)=240
240 % 10 = 0
So 199798-84-0 is a valid CAS Registry Number.
InChI:InChI=1/C29H43FO2/c1-6-29(32,7-2)17-8-10-20(3)25-14-15-26-22(11-9-16-28(25,26)5)12-13-23-18-24(31)19-27(30)21(23)4/h8,12-14,17,20,24,26-27,31-32H,4,6-7,9-11,15-16,18-19H2,1-3,5H3/b17-8+,22-12+,23-13+/t20-,24+,26-,27-,28+/m0/s1
199798-84-0Relevant articles and documents
SYNTHESIS OF 1α-FLUORO-25-HYDROXY-16-23E-DIENE-26,27-BISHOMO-20-EPI-CHOLECALCIFEROL
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Page/Page column 17; 65, (2008/12/07)
The invention provides a method of producing 20-methyl vitamin D3 compounds of formula (I). The method includes hydroxylation, carbonyl reduction, fluoride substitution, epoxide deoxygenation, and Wittig-type couplings.
NOVEL METHOD
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, (2008/06/13)
There is provided a method of prevention of adhesions, eg surgical adhesions, which comprises using a vitamin D compound.
SYNTHESIS OF 1α-FLUORO-25-HYDROXY-16-23E-DIENE-26,27-BISHOMO-20-EPI-CHOLECALCIFEROL
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Page/Page column 75-76, (2008/06/13)
The invention provides a method of producing 20-methyl vitamin D3 compounds of formula (I). The method includes allylic and olefin oxidation, decarbonylation, carbonyl reduction, fluoride substitution, epoxide deoxygenation, and Wittig-type couplings.
NOVEL METHOD
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Page/Page column 28-29; 44-45, (2010/11/28)
The invention provides for the use of Vitamin D compounds such as 1-alpha-fluoro-25- hydroxy-16,23E-diene-26,27-bishomo-20-epi-cholecalciferol, in the prevention or treatment of prostate cancer.
USE OF VITAMIN D COMPOUNDS TO TREAT ENDOMETRIOSIS
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Page/Page column 111-112, (2010/11/24)
The use of vitamin D compounds in the treatment or prevention of endometriosis, methods for the treatment or prevention of endometriosis by administering a vitamin D compound, and compounds for use therein.
