Synthesis and preliminary cytotoxicity study of glucuronide derivatives of CC-1065 analogues
Glucuronide derivatives of CBI-bearing CC-1065 analogues have been synthesized, and their cytotoxicities tested against U937 leukemia cells. The new compounds show potent antitumor activity in vitro. Compounds 1 and 2, and their corresponding glucuronides
Wang, Yuqiang,Yuan, Huiling,Wright, Susan C.,Wang, Hong,Larrick, James W.
p. 1569 - 1575
(2007/10/03)
-
The present invention relates to novel DNA alkylating agents and the prodrugs of these agents which are useful as antitumor agents and DNA labelling agents. The compounds are hydroxy dihydrobenzindole oligopeptides and prodrugs thereof wherein the monomeric constituents are derived from monocyclic or bicyclic heterocyclic aromatic residues.
-
(2008/06/13)
More Articles about upstream products of 199806-23-0