- Tetradentate cyclometallatin (II) and palladium (II) complex luminescent material containing quinoline structural unit and application thereof
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The invention relates to the technical field of organic luminescent materials, and provides a metal platinum (II) and a palladium (II) complex luminescent material containing a quinoline structural unit, as shown below. Compared with the bidentate ligand platinum complex, the cyclometallatin (II) and the palladium (II) complex molecule based on the tetradentate ligand provided by the invention have strong rigidity, can effectively inhibit non-radiative transition caused by molecule vibration, greatly improve the quantum efficiency, and have wide application prospects in the fields OLED display, illumination and the like.
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- Selenophenol quinoline derivative as well as preparation method and application thereof
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The invention discloses a selenophenol quinoline derivative as well as a preparation method and application thereof. The structure of the selenophenol quinoline derivative is shown as a formula I, a formula II or a formula III, wherein R1 is hydrogen, a C1-6 alkyl group, a C1-6 alkoxy group, a substituted ketone group, a phenyl group, a benzyl group, a substituted phenyl group or a substituted benzyl group; R1 is a monovalent metal cation; R2 is one or more of hydrogen, halogen, a C1-4 alkyl group, a C1-4 alkoxy group or a C1-4 haloalkyl group; R3 is a substituted five-membered heterocyclicring or a substituted six-membered heterocyclic ring; and a heteroatom is one or more of N, O, S or Se. The compound disclosed by the invention is novel in structure, simple in preparation process and relatively good in inhibition effect on various cancer cells, particularly the compounds 34, 44, 45, 98, 104, 115 and 116 have excellent inhibition effects on various cancer cells, the effects of the compounds are equivalent to those of a positive control DDP, and the compounds can be used to prepare anti-cancer drugs to be applied under 5 [mu]M or below, so that the prospect is wide.
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Paragraph 0061; 0068-0071
(2020/12/30)
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- Novel 2, 8-bit derivatives of quinolines attenuate Pseudomonas aeruginosa virulence and biofilm formation
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Signal molecules are stimulators of multiple quroum-sensing virulence and biofilm formation. Small molecule analogues have been suspected as a potent inhibitor in therapeutic strategy. Herein, we synthesized a series of small molecule compounds from the 2
- Qiu, Man-Na,Wang, Fang,Chen, Si-Yu,Wang, Peng-Cheng,Fu, Yu-Hang,Liu, Yuan-Yuan,Wang, Xuan,Wang, Fan-Bei,Wang, Chao,Yang, Hong-Wen,Wu, Yang,Zhu, Shi-Ying,Zhou, Hai-Bo,Chen, Wei-Min,Lin, Jing,Zheng, Jun-Xia,Sun, Ping-Hua
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p. 749 - 754
(2019/01/09)
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- Organic optoelectronic functional material and application thereof
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The invention belongs to the field of organic electroluminescent devices, and discloses an organic electroluminescent material containing a diquinolyl structure and application of the organic electroluminescent material. By using the organic electroluminescent material provided by the invention as an electron transport material, the produced device has good electron mobility and relatively-balanced current carrier transmission property, and the improvement efficiency of the device is facilitated. In addition, the organic electroluminescent material provided by the invention also can be furtherblended with a hole type main body material so as to form an exciplex; by using the exciplex as a co-subject material, the efficiency and the stability of the produced device are both improved obviously.
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- Regioselective bromination of fused heterocyclic N-oxides
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A mild method for the regioselective C2-bromination of fused azine N-oxides is presented, employing tosic anhydride as the activator and tetra-n-butylammonium bromide as the nucleophilic bromide source. The C2-brominated compounds are produced in moderate to excellent yields and with excellent regioselectivity in most cases. The potential extension of this method to other halogens, effecting C2-chlorination with Ts2O/TBACl is also presented. Finally, this method could be incorporated into a viable one-pot oxidation/bromination process, using methyltrioxorhenium/urea hydropgen peroxide as the oxidant.
- Wengryniuk, Sarah E.,Weickgenannt, Andreas,Reiher, Christopher,Strotman, Neil A.,Chen, Ke,Eastgate, Martin D.,Baran, Phil S.
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supporting information
p. 792 - 795
(2013/04/10)
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- Heteroaryl cross-coupling as an entry toward the synthesis of lavendamycin analogues: A model study
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(Chemical Equation Presented) ABC analogues of the antitumor antibiotic lavendamycin, which contain the key metal chelation site and redox-active quinone unit essential for biological activity, were prepared via the palladium(0)-catalyzed cross-coupling reaction of various 2-haloheteroaromatics with 2-stannylated pyridines and quinolines. Using the Stille reaction, 2-bromo substituted quinolines and 1-bromoisoquinolines were found to undergo efficient coupling with 2-pyridinylstannanes to provide unsymmetrical heterobiaryl derivatives. While the Stille reaction using the reverse coupling partners (i.e., 2-quinolinylstannanes and haloheteroaromatics) had not received much attention in the literature, we found that this alternative coupling reaction efficiently provided several new heterobiaryl derivatives. The gold-catalyzed intramolecular cycloisomerization of N-(prop-2-ynyl)-1H-indole-2-carboxamide smoothly afforded a β-carbolinone derivative that was subsequently used for a Pd(0)-catalyzed cross-coupling directed toward the synthesis of lavendamycin analogues.
- Verniest, Guido,Wang, Xingpo,De Kimpe, Norbert,Padwa, Albert
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experimental part
p. 424 - 433
(2010/03/30)
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