- Rapid and convenient method for the synthesis of symmetrical disulfides
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We present here the results on the use of 1,3,5-triazo-2,4,6- triphosphorine-2,2,4,4,6,6-hexachloride as an efficient promoter in the conversion of thiols to the corresponding symmetrical disulfides under solvent-free conditions. Aromatic thiols bearing electron donating and electron withdrawing groups, heteroaromatic, and alkyl thiols reacted efficiently to afford excellent yields of disulfides in short reaction times after easy work-up. Different functional groups including carboxyl, methoxy, methylthio, and halogen are tolerated. Supplementary materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfer, and Silicon and the Related Elements for the following free supplemental files: Additional figures and tables.
- Bahrami, Kiumars,Khodaei, Mohammad M.,Shakibaian, Vida,Targhan, Homa
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p. 981 - 988
(2013/09/02)
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- Aerobic oxidation of thioles to disulfides catalyzed by mixed-addenda vanadium (V) substituted heteropolyacids
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The oxidation of thiols to related disulfides using mixed-addenda heteropolyacids as catalyst under mild condition has been studied. This system provides an efficient, convenient, and practical method for the syntheses of symmetrical disulfides. In this w
- Rezvani, M. A.,Harutyunyan, R.,Heravi, Majid M.
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p. 1232 - 1236,5
(2020/09/02)
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- Aerobic oxidation of thiols to disulfides catalyzed by diaryl tellurides under photosensitized conditions
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Aerobic oxidation of thiols is efficiently catalyzed by diaryl tellurides such as bis(4-methoxyphenyl) telluride under photosensitized conditions to give the corresponding disulfides in good to excellent yields. In this catalytic system, the tellurone oligomer, produced by the reaction of a telluride with singlet oxygen, is assumed to be the active species and is capable of oxidizing 4 equiv of a thiol.
- Oba, Makoto,Tanaka, Kazuhito,Nishiyama, Kozaburo,Ando, Wataru
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experimental part
p. 4173 - 4177
(2011/06/26)
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- H5PV2Mo10O40 as an efficient catalyst for the oxidation of thiols to the corresponding disulfides using hydrogen peroxide as the oxidant
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The H5PV2Mo10O40 catalyzed the oxidation of thiols to their homodisulfides using hydrogen peroxide as the oxidant under mild conditions is reported. This system provides an efficient, convenient and practical me
- Shojaei, Abdollah Fallah,Rezvani, Mohamad Ali,Heravi, Majid
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experimental part
p. 955 - 963
(2012/04/04)
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- Aerobic oxidation of some arylthiols catalyzed by a new manganese (III) schiff-base complex
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Bis(2-hydroxybenzene)phthaldiimine (BHBPDI) as a new quadridentate Schiff base ligand and its [Mn(III)(BHBPDI)Cl] complex were synthesized and characterized by analytical and spectral data (MS, FT-IR, UV-Vis, 1H NMR). The aerobic oxidation of thiols catalyzed by Mn(III)-complex using molecular oxygen was studied at room temperature. The reaction proceeded to yield the corresponding symmetric disulfides in good to high yields. The reaction was retarded when the reaction mixture was saturated with nitrogen gas. This system provides an efficient and convenient method for the oxidation of thiols to symmetric disulfides.
- Montazerozohori, Morteza,Fradombe, Leila Zamani
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experimental part
p. 509 - 515
(2010/06/17)
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- Efficient and convenient oxidation of thiols to symmetrical disulfide with silica-PCl5/NaNO2 in water
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A very simple, environmentally benign, cost-effective, and efficient synthesis of disulfides from thiols using silica-PCl5/NaNO2 in aqueous medium has been described. The reaction was found to occur rapidly under mild conditions, and disulfides were obtained easily through a simple workup.
- Pathak, Uma,Pandey, Lokesh Kumar,Mathur, Sweta
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experimental part
p. 2923 - 2927
(2009/12/03)
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- Fast and highly efficient solid state oxidation of thiols
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A fast and efficient solid state method for the chemoselective room temperature oxidative coupling of thiols to afford their corresponding disulfides using inexpensive and readily available moist sodium periodate as the reagent is described. The reaction was applicable to a variety of thiols giving high yields after short reaction times. Comparison of yield/time ratios of this method with some of those reported in the literature shows the superiority of this reagent over others under these conditions.
- Montazerozohori, Morteza,Joohari, Shiva,Karami, Bahador,Haghighat, Nasrin
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p. 694 - 702
(2008/02/01)
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- Bis (salicylaldehyde-1,2-phenylene diimine)Mn(III) chloride (Mn(III)-salophen) catalysed oxidation of thiols to symmetrical disulfides using urea hydrogen peroxide (UHP) as mild and efficient oxidant
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A variety of thiols were oxidised efficiently by a catalytic amount of Mn(III)-salophen 1 in the presence of urea hydrogen peroxide adduct 2 as a convenient and mild oxidant to afford the corresponding disulfides in high yields in quite short reaction tim
- Karami, Bahador,Montazerozohori, Morteza,Habibi, Mohammad Hossein
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p. 490 - 492
(2007/10/03)
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- Organosulfur compounds as pre-exposure therapy for threat agents.
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A series of symmetric (Ar-S-S-Ar) and unsymmetric (Ar-S-S-CH2CH2NH3+Cl-) disulfides have been prepared and evaluated as potential cyanoprotective agents. Target compounds have been prepared by known methods and/or methods developed by us specifically for this program, e.g. reaction of a thiol with 2,2'-dithiobis(benzothiazole) (BT-S-S-BT) followed by reaction with a second thiol. Both 4-methoxyphenyl disulfide and 2-aminoethyl-4-methoxyphenyl disulfide hydrochloride are cyanoprotective against 2-LD50 of injected cyanide. Evaluation of both symmetric and unsymmetric related disulfides indicates that structural requirements for cyanoprotective activity are stringent and strongly suggest that protection is enzyme mediated. In addition to cyanoprotective action, initial results suggest that unsymmetric disulfides may evolve into effective antimustard agents.
- Ternay Jr.,Brzezinska,Sorokin,Cook,Lyaschenko
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- Method of producing bis(4-alkylthiophenyl) disulfides
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The present invention relates to a method of producing bis(4-alkylthiophenyl) disulfides characterized by (a) reducing directly a 4-alkylthiobenzenesulfonyl chloride, or (b) oxidizing a 4-alkylthiobenzenethiol obtained by reducing a 4-alkylthiobenzenesulfonyl chloride. The present invention is capable of producing the compound below useful as an intermediate of pharmaceuticals. STR1
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- Methanediphosphonate derivative, its manufacturing process and its pharmaceutical applications
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The present invention relates to a methanediphosphonate derivative, its manufacturing process and pharmaceutical applications, that is represented with the following formula: STR1 (wherein, B is either hydrogen, an alkyl group, hydroxyl group, alkoxy grou
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