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200704-37-6

Morpholine, 2,6-dimethyl-4-(2-propynyl)- (9CI) is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 200704-37-6 Structure

  • Basic information

    1. Product Name: Morpholine, 2,6-dimethyl-4-(2-propynyl)- (9CI)
    2. Synonyms: Morpholine, 2,6-dimethyl-4-(2-propynyl)- (9CI)
    3. CAS NO:200704-37-6
    4. Molecular Formula: C9H15NO
    5. Molecular Weight: 153.22
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 200704-37-6.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: Morpholine, 2,6-dimethyl-4-(2-propynyl)- (9CI)(CAS DataBase Reference)
    10. NIST Chemistry Reference: Morpholine, 2,6-dimethyl-4-(2-propynyl)- (9CI)(200704-37-6)
    11. EPA Substance Registry System: Morpholine, 2,6-dimethyl-4-(2-propynyl)- (9CI)(200704-37-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 200704-37-6(Hazardous Substances Data)

200704-37-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 200704-37-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,0,7,0 and 4 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 200704-37:
(8*2)+(7*0)+(6*0)+(5*7)+(4*0)+(3*4)+(2*3)+(1*7)=76
76 % 10 = 6
So 200704-37-6 is a valid CAS Registry Number.

200704-37-6Downstream Products

200704-37-6Relevant articles and documents

Discovery of GSK251: A Highly Potent, Highly Selective, Orally Bioavailable Inhibitor of PI3Kδ with a Novel Binding Mode

Down, Kenneth,Amour, Augustin,Anderson, Niall A.,Barton, Nick,Campos, Sebastien,Cannons, Edward P.,Clissold, Cole,Convery, Maire A.,Coward, John J.,Doyle, Kevin,Duempelfeld, Birgit,Edwards, Christopher D.,Goldsmith, Michael D.,Krause, Jana,Mallett, David N.,McGonagle, Grant A.,Patel, Vipulkumar K.,Rowedder, James,Rowland, Paul,Sharpe, Andrew,Sriskantharajah, Srividya,Thomas, Daniel A.,Thomson, Douglas W.,Uddin, Sorif,Hamblin, J. Nicole,Hessel, Edith M.

supporting information, p. 13780 - 13792 (2021/09/28)

Optimization of a previously reported lead series of PI3Kδ inhibitors with a novel binding mode led to the identification of a clinical candidate compound 31 (GSK251). Removal of an embedded Ames-positive heteroaromatic amine by reversing a sulfonamide followed by locating an interaction with Trp760 led to a highly selective compound 9 . Further optimization to avoid glutathione trapping, to enhance potency and selectivity, and to optimize an oral pharmacokinetic profile led to the discovery of compound 31 (GSK215) that had a low predicted daily dose (45 mg, b.i.d) and a rat toxicity profile suitable for further development.

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