200810-26-0

Basic information

• Product Name: [3,3'-Biphenanthrene]-4,4'-diol, 2,2'-diphenyl-
• Synonyms: [3,3'-Biphenanthrene]-4,4'-diol, 2,2'-diphenyl-;3-(4-hydroxy-2-phenylphenanthren-3-yl)-2-phenylphenanthren-4-ol
• CAS NO: 200810-26-0
• Molecular Formula: C₄₀H₂₆O₂
• Molecular Weight: 538.63324
• Mol File: 200810-26-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: [3,3'-Biphenanthrene]-4,4'-diol, 2,2'-diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: [3,3'-Biphenanthrene]-4,4'-diol, 2,2'-diphenyl-(200810-26-0)
• EPA Substance Registry System: [3,3'-Biphenanthrene]-4,4'-diol, 2,2'-diphenyl-(200810-26-0)

Safety Data

• Hazardous Substances Data: 200810-26-0(Hazardous Substances Data)

Usage

Uses

Used in Organic Chemistry:
[3,3'-Biphenanthrene]-4,4'-diol, 2,2'-diphenylis used as a building block for the synthesis of novel polymers and complex organic molecules due to its unique structure and properties.
Used in Materials Science:
[3,3'-Biphenanthrene]-4,4'-diol, 2,2'-diphenylis used as a component in the development of new materials with specific properties, such as improved stability or enhanced performance, owing to its distinctive molecular structure.
The unique structure of [3,3'-Biphenanthrene]-4,4'-diol, 2,2'-diphenylmakes it an interesting subject for further research and potential commercial development in various industries.

Upstream product

• 536-74-3 phenylacetylene 
• 37859-25-9 2-naphthylacetyl chloride 
• 1315307-03-9 C₃₂H₂₂O₂ 
• 581-96-4 2-naphthylacetic acid 
• 175223-47-9 Acetic acid 4-methoxy-2-phenyl-phenanthren-1-yl ester 
• 175223-64-0 2-phenyl-4-phenanthrol 

Downstream Products

• 175223-69-5 rac-VAPOL hydrogen phosphate 
• 1037075-04-9 [B((S)-VAPOL^(2-))(phenoxy)] 
• 1037075-02-7 [B₂O((S)-VAPOL^(2-))(phenoxy)2] 
• 586952-28-5 (dppe)Pt(S-VAPOL) 

Relevant articles and documents

The iso-VAPOL ligand: Synthesis, solid-state structure and its evaluation as a BOROX catalyst

The new vaulted biaryl ligand iso-VAPOL is an isomer of VAPOL but has the chiral pocket of VANOL. The synthesis of iso-VAPOL involves a cycloaddition/electrocyclization cascade (CAEC) similar to one that is used for VAPOL except that the starting material

Synthesis, resolution, and determination of absolute configuration of a vaulted 2,2′-binaphthol and a vaulted 3,3′-biphenanthrol (VAPOL)

Two methods for the synthesis of vaulted biaryls were developed involving the reactions of carbene complexes with alkynes and the [2 + 2] cycloaddition of ketenes. The final step in the synthesis of 3,3′-diphenyl-[2,2′-binaphthalene]-1,1′-diol (39) and 2,2′-diphenyl-[3,3′-biphenanthrene]-4,4′-diol (47) (VAPOL) was phenol coupling of the 3-phenyl-1-naphthol (14) and the 2-phenyl-4-phenanthrol (28), respectively. The naphthol 14 could be prepared from the thermolysis of phenylacetyl chloride in the presence of phenylacetylene or from the benzannulation of the pentacarbonyl(phenylmethoxymethylene)chromium(0) (15) with phenylacetylene which upon an acetylative workup gives O-acetyl-4-methoxy-2-phenyl-1-naphthol (16). The reductive cleavage of the acetoxy group in 16 was unexpectedly affected by aluminum chloride and ethanethiol which were used to cleave the methyl ether. In a similar manner, the phenanthrol 28 could either be prepared from the 1-naphthylacetyl chloride (30) or pentacarbonyl-(1-naphthylmethoxymethylene)chromium(0) (21). A new procedure for the preparation of carbene complexes was developed utilizing dimethyl sulfate as methylating agent. Unlike the benzannulation of the phenyl complex 15, the benzannulation of the naphthylcarbene complex 21 with phenylacetylene gave a side product which resulted from the incorporation of 2 equiv of the alkyne. This side product could be minimized by the proper control of the concentration of the alkyne. The phenol coupling of the 3-phenyl-1-naphthol with ferric chloride gave 2,2′-diphenyl-[2,2′-binaphthalene]-4,4′-diol (38) and with air as oxidant gave the of 3,3′-diphenyl-[2,2′-binaphthalene]-1,1′-diol (39). Oxidative coupling of the 2-phenyl-4-phenanthrol (28) with air gave 2,2′-diphenyl-[3,3′-biphenanthrene]-4,4′-diol (47) (VAPOL), but the same coupling with 2-tert-butyl-4-phenanthrol (34) failed. The 2,2′-binaphthol 39 was resolved via its cyclic diester with phosphoric acid by salt formation with (-)-brucine, and the 3,3′-biphenanthrol 47 was resolved via its cyclic deiester with phosphoric acid (49) by salt formation with (-)-cinchonidine. The configuration of (-)-39 was shown to be S from an X-ray analysis of the brucine salt, and the configuration of (+)-47 was shown to be S from an X-ray analysis the amide (S,S)-54 derived from 49 and (S)-α-methylbenzylamine.