200815-83-4

Basic information

• Product Name: (5-METHYL-4-PHENYL-4 H-[1,2,4]TRIAZOL-3-YLSULFANYL)-ACETIC ACID
• Synonyms: (5-METHYL-4-PHENYL-4 H-[1,2,4]TRIAZOL-3-YLSULFANYL)-ACETIC ACID;[(5-METHYL-4-PHENYL-4H-1,2,4-TRIAZOL-3-YL)THIO]ACETIC ACID;BUTTPARK 70\41-23;2-[(5-methyl-4-phenyl-1,2,4-triazol-3-yl)sulfanyl]acetic acid;2-[(5-methyl-4-phenyl-1,2,4-triazol-3-yl)sulfanyl]ethanoic acid;2-[(5-methyl-4-phenyl-1,2,4-triazol-3-yl)thio]acetic acid;BAS 02071229;ST5260026
• CAS NO: 200815-83-4
• Molecular Formula: C₁₁H₁₁N₃O₂S
• Molecular Weight: 249.29
• Mol File: 200815-83-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (5-METHYL-4-PHENYL-4 H-[1,2,4]TRIAZOL-3-YLSULFANYL)-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (5-METHYL-4-PHENYL-4 H-[1,2,4]TRIAZOL-3-YLSULFANYL)-ACETIC ACID(200815-83-4)
• EPA Substance Registry System: (5-METHYL-4-PHENYL-4 H-[1,2,4]TRIAZOL-3-YLSULFANYL)-ACETIC ACID(200815-83-4)

Safety Data

• Hazardous Substances Data: 200815-83-4(Hazardous Substances Data)

Upstream product

• 79-08-3 bromoacetic acid 
• 6232-82-2 3-mercapto-5-methyl-4-phenyl-4H-1,2,4-triazole 
• 13153-00-9 N⁴-phenyl acetic acid thio-semicarbazide 
• 5351-69-9 4-Phenyl-3-thiosemicarbazide 
• 1428354-41-9 4-ethoxycarbonyl-1-{[(4-phenyl-5-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetyl} thiosemicarbazide 
• 84210-55-9 ethyl [(4-phenyl-5-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetate 
• 62373-05-1 [(4-phenyl-5-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetohydrazide 
• 6232-82-2 5-methyl-4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione 

Downstream Products

• 354995-89-4 N-(2-chloro-phenyl)-2-(5-methyl-4-phenyl-4H-[1,2,4]triazol-3-ylsulfanyl)-acetamide 

Relevant articles and documents

Synthesis and in vitro antimicrobial activity of new 4-phenyl-5-methyl-4H-1,2,4-triazole-3-thione derivatives

This study presents the synthesis, spectral analysis and antimicrobial evaluation of a new series of substituted 1,2,4-triazole (5a-i) and 1,3,4-thiadiazole derivatives (9a, c, g, h). New compounds were obtained by cyclization reaction of acyl thiosemicarbazide derivatives in the presence of alkaline and acidic media. All synthesized compounds were screened for their in vitro antimicrobial activities. Nine of the compounds had potential activity against Gram-positive bacteria (MIC = 3.91-500 μg/mL). Some compounds showed good activity especially against: Micrococcus luteus ATCC 10240 (MIC = 3.91-31.25 μg/mL), Bacillus subtilis ATCC 6633 (MIC = 15.63-62.5 μg/mL), and Staphylococcus aureus ATCC 25923 (MIC = 15.63-125 μg/mL).

Synthesis and in vitro antimicrobial activity of new 4-phenyl-5-methyl-4H- 1,2,4-triazole-3-thione derivatives

This study presents the synthesis, spectral analysis and antimicrobial evaluation of a new series of substituted 1,2,4-triazole (5a-i) and 1,3,4-thiadiazole derivatives (9a, c, g, h). New compounds were obtained by cyclization reaction of acyl thiosemicarbazide derivatives in the presence of alkaline and acidic media. All synthesized compounds were screened for their in vitro antimicrobial activities. Nine of the compounds had potential activity against Gram-positive bacteria (MIC=3.91-500 g/mL). Some compounds showed good activity especially against: Micrococcus luteus ATCC 10240 (MIC=3.91-31.25 g/mL), Bacillus subtilis ATCC 6633 (MIC=15.63- 62.5 /mL), and Staphylococcus aureus ATCC 25923 (MIC=15.63-125 g/mL).

Synthesis and biological evaluations of sulfanyltriazoles as novel HIV-1 non-nucleoside reverse transcriptase inhibitors

A novel sulfanyltriazole was discovered as an HIV-1 non-nucleoside reverse transcriptase inhibitor via HTS using a cell-based assay. Chemical modifications and molecular modeling studies were carried out to establish its SAR and understand its interactions with the enzyme. These modifications led to the identification of sulfanyltriazoles with low nanomolar potency for inhibiting HIV-1 replication and promising activities against selected NNRTI resistant mutants. These novel and potent sulfanyltriazoles could serve as advanced leads for further optimization.