A pyrimidin-4-one compound can be prepared in a high yield by reacting an aminoarylcarboxylic acid compound with an organic acid compound in the presence of a nitrogen atom-containing compound under relatively simple and moderate reaction conditions.
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Page/Page column 7; 8
(2008/06/13)
FUSED PYRAZOLE DERIVATIVES AS TGF-BETA SIGNAL TRANSDUCTION INHIBITORS FOR THE TREATMENT OF FIBROSIS AND NEOPLASMS
The disclosed invention is directed to compounds of the formula: Formula (I) and methods of using these compounds.
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Page/Page column 18
(2010/02/14)
PYRAZOLES AND METHODS OF MAKING AND USING THE SAME
The invention is based on the discovery that compounds of formula I possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. In one embodiment, the invention features a compound of formula I (I).
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Page 30-31
(2010/02/08)
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