Highly Enantioselective Catalytic Addition of Grignard Reagents to N-Heterocyclic Acceptors
General methods to prepare chiral N-heterocyclic molecular scaffolds are greatly sought after because of their significance in medicinal chemistry. Described here is the first general catalytic methodology to access a wide variety of chiral 2- and 4-substituted tetrahydro-quinolones, dihydro-4-pyridones, and piperidones with excellent yields and enantioselectivities, utilizing a single catalyst system.
Guo, Yafei,Harutyunyan, Syuzanna R.
p. 12950 - 12954
(2019/08/07)
More Articles about upstream products of 20146-50-3
