Novel one-pot Mannich-type reaction in water: Indium trichloride-catalyzed condensation of aldehydes, amines and silyl enol ethers for the synthesis of β-amino ketones and esters
Novel one-pot Mannich-type reaction between aldehydes, amines and silyl enol ethers is catalyzed by indium trichloride in water to give β-amino ketones and esters in moderate to good yields.
Three component synthesis of β-amino carbonyl compounds using indium trichloride-catalyzed one-pot Mannich-type reaction in water
The use of indium trichloride as catalyst in a one-pot Mannich reaction in water gives high yields for the formation of β-aminoketones/esters/acids is described. The catalyst can be recycled when the reaction is complete (Loh T.-P.; Wei L.-L. Tetrahedron Lett. 1998, 39, 323). (C) 2000 Elsevier Science Ltd.
Loh, Teck-Peng,Liung, Sarah B. K. W.,Tan, Kee-Leng,Wei, Lin-Li
p. 3227 - 3237
(2007/10/03)
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