202074-27-9

Basic information

• Product Name: (E)-1,1,1-TRIFLUORO-4-(1H-PYRROL-2-YL)BUT-3-EN-2-ONE
• Synonyms: (E)-1,1,1-TRIFLUORO-4-(1H-PYRROL-2-YL)BUT-3-EN-2-ONE
• CAS NO: 202074-27-9
• Molecular Formula: C8H6F3NO
• Molecular Weight: 189.13
• Mol File: 202074-27-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (E)-1,1,1-TRIFLUORO-4-(1H-PYRROL-2-YL)BUT-3-EN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1,1,1-TRIFLUORO-4-(1H-PYRROL-2-YL)BUT-3-EN-2-ONE(202074-27-9)
• EPA Substance Registry System: (E)-1,1,1-TRIFLUORO-4-(1H-PYRROL-2-YL)BUT-3-EN-2-ONE(202074-27-9)

Safety Data

• Hazardous Substances Data: 202074-27-9(Hazardous Substances Data)

Upstream product

• 109-97-7 pyrrole 
• 202074-35-9 1,1,1-trifluoro-4-(phenylsulfonyl)but-3-ene-2,2-diol 
• 59938-06-6 (E)-4-Ethoxy-1,1,1-trifluoro-3-buten-2-one 

Relevant articles and documents

A novel efficient synthesis of heteroaryl substituted α,β-unsaturated trifluoromethyl ketones

A synthesis of a novel electrophilic reagent 1,1,1-trifluoro-4-(phenylsulfonyl)-but-3-ene-2,2-diol 2 is described. The reaction of 2 with various electron-rich heteroaromatics such as furans, pyrroles, indoles is investigated. The addition-elimination reaction proceeds under mild conditions stereospecifically and permits a novel one-step procedure for the preparation of trifluoroacetylvinyl substituted heterocycles in high yield. In all cases only E-isomers of unsaturated CF3 ketones were obtained.

Synthesis of indolyl-and pyrrolyl-substituted trifluoromethyl-containing enones

Indoles and pyrroles react with (E)-4-ethoxy-1,1,1-trifluoro-3-buten-2-one and 3-(ethoxymethylene)-1,1,1,5,5,5-hexafluoro-2,4-pentanedione in the presence of ZnCl2 to give hetaryl-substituted enones (enediones) containing, respectively, one or