- Visual detection of copper(II) by azide- and alkyne-functionalized gold nanoparticles using click chemistry
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(Figure Presented) Just one click, and the color's gone: In the presence of Cu2+ with sodium ascorbate as a reductant, gold nanoparticles that have azide- and alkyne-terminated groups undergo aggregation as the result of CuI-catalyzed click chemistry. This process can be monitored by eye without the aid of instruments (NPs=nanoparticles).
- Zhou, Yang,Wang, Shixing,Zhang, Ke,Jiang, Xingyu
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Read Online
- Hamilton Receptor-Mediated Self-Assembly of Orthogonally Functionalized Au and TiO2 Nanoparticles
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A new prototype of reversible self-assembly between functionalized gold and titanium dioxide nanoparticles (NPs) utilizing hydrogen bonding interactions was developed and established. The gold nanoparticles were functionalized with a Hamilton-receptor fun
- Ali, Muhammad,Hasen?hrl, Dominik H.,Zeininger, Lukas,Müllner, Alexander R. M.,Peterlik, Herwig,Hirsch, Andreas
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Read Online
- Formation of carbohydrate-functionalised polystyrene and glass slides and their analysis by MALDI-TOF MS
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Glycans functionalised with hydrophobic trityl groups were synthesised and adsorbed onto polystyrene and glass slides in an array format. The adsorbed glycans could be analysed directly on these minimally conducting surfaces by MALDI-TOF mass spectrometry
- Weissenborn, Martin J.,Wehner, Johannes W.,Gray, Christopher J.,Sardzik, Robert,Eyers, Claire E.,Lindhorst, Thisbe K.,Flitsch, Sabine L.
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Read Online
- Fluorovinylsulfones and -Sulfonates as Potent Covalent Reversible Inhibitors of the Trypanosomal Cysteine Protease Rhodesain: Structure-Activity Relationship, Inhibition Mechanism, Metabolism, and in Vivo Studies
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Rhodesain is a major cysteine protease of Trypanosoma brucei rhodesiense, a pathogen causing Human African Trypanosomiasis, and a validated drug target. Recently, we reported the development of α-halovinylsulfones as a new class of covalent reversible cysteine protease inhibitors. Here, α-fluorovinylsulfones/-sulfonates were optimized for rhodesain based on molecular modeling approaches. 2d, the most potent and selective inhibitor in the series, shows a single-digit nanomolar affinity and high selectivity toward mammalian cathepsins B and L. Enzymatic dilution assays and MS experiments indicate that 2d is a slow-tight binder (Ki = 3 nM). Furthermore, the nonfluorinated 2d-(H) shows favorable metabolism and biodistribution by accumulation in mice brain tissue after intraperitoneal and oral administration. The highest antitrypanosomal activity was observed for inhibitors with an N-terminal 2,3-dihydrobenzo[b][1,4]dioxine group and a 4-Me-Phe residue in P2 (2e/4e) with nanomolar EC50 values (0.14/0.80 μM). The different mechanisms of reversible and irreversible inhibitors were explained using QM/MM calculations and MD simulations.
- Jung, Sascha,Fuchs, Natalie,Johe, Patrick,Wagner, Annika,Diehl, Erika,Yuliani, Tri,Zimmer, Collin,Barthels, Fabian,Zimmermann, Robert A.,Klein, Philipp,Waigel, Waldemar,Meyr, Jessica,Opatz, Till,Tenzer, Stefan,Distler, Ute,R?der, Hans-Joachim,Kersten, Christian,Engels, Bernd,Hellmich, Ute A.,Klein, Jochen,Schirmeister, Tanja
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p. 12322 - 12358
(2021/09/02)
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- NANOPARTICLES FOR DIAGNOSIS AND DRUG DELIVERY
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The present invention relatesto a nanoparticle having a size comprised from 2 to 300 nm comprising: (i) a core comprising on its surface a noble metal selected from gold, silver or platinum, and (ii) an optionally positively charged amphiphilic linker comprising a hydrophobic C1-C20 alkyl thiolate moiety and a hydrophilic moietywhich is optionally hydrophilic positively charged. The invention also provides nanovectors comprising the nanoparticles of the invention and a compound of interest,such as a pharmaceutically active agent, in particular an anti-tumoral agent. Also provided are nanoparticles and nanovectors as defined above for diagnosis or for the prevention and/or treatment of a disease, in particular cancer.
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Page/Page column 44
(2017/04/11)
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- Enzyme cascade methods for E-TRACE assay signal amplification
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The disclosure also relates to novel methods for detection of biological targets using amplification steps in conjunction with conversion of functional groups attached to a transitional metal complex, resulting in quantifiable electrochemical signal at tw
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Page/Page column 49
(2016/02/26)
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- Resettable, multi-readout logic gates based on controllably reversible aggregation of gold nanoparticles
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A resettable logic system based on spiropyran-modified gold nanoparticles that is capable of AND, OR, and INHIBIT logic operations has been constructed. Several methods can record the output of this process, including the naked eye, UV/Vis spectroscopy, d
- Liu, Dingbin,Chen, Wenwen,Sun, Kang,Deng, Ke,Zhang, Wei,Wang, Zhuo,Jiang, Xingyu
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supporting information; scheme or table
p. 4103 - 4107
(2011/07/07)
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