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202592-24-3

"6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-triMethyl-, (6R)-" is a complex organic compound with a unique chemical structure. It is characterized by a thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine core, which is a fused ring system containing both thiophene and triazole moieties. The compound features a 6-acetic acid group, indicating the presence of a carboxylic acid functionality at the 6-position. Additionally, it has a 4-(4-chlorophenyl) substituent, which introduces a chlorophenyl group at the 4-position, and a 2,3,9-trimethyl pattern, meaning there are methyl groups at the 2, 3, and 9 positions of the molecule. The (6R)- configuration specifies the chirality of the compound, indicating that the hydroxyl group at the 6-position is on the right side when looking at the molecule from a specific perspective. 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-triMethyl-, (6R)- is likely to be of interest in medicinal chemistry due to its potential as a precursor or intermediate in the synthesis of pharmaceuticals, given its intricate structure and functional groups.

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  • 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-triMethyl-, (6R)-

    Cas No: 202592-24-3

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  • 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-triMethyl-, (6R)-

    Cas No: 202592-24-3

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  • 202592-24-3 Structure

  • Basic information

    1. Product Name: 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-triMethyl-, (6R)-
    2. Synonyms: 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-triMethyl-, (6R)-;2-((6R)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetic acid
    3. CAS NO:202592-24-3
    4. Molecular Formula: C19H17ClN4O2S
    5. Molecular Weight: 400.88188
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 202592-24-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 661.6±65.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.51±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 4.11±0.10(Predicted)
    10. CAS DataBase Reference: 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-triMethyl-, (6R)-(CAS DataBase Reference)
    11. NIST Chemistry Reference: 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-triMethyl-, (6R)-(202592-24-3)
    12. EPA Substance Registry System: 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-triMethyl-, (6R)-(202592-24-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 202592-24-3(Hazardous Substances Data)

202592-24-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 202592-24-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,2,5,9 and 2 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 202592-24:
(8*2)+(7*0)+(6*2)+(5*5)+(4*9)+(3*2)+(2*2)+(1*4)=103
103 % 10 = 3
So 202592-24-3 is a valid CAS Registry Number.

202592-24-3Relevant articles and documents

METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE

-

, (2021/08/13)

The present disclosure relates to compounds and methods for modulating the expression of dmpk, and treating diseases and conditions in which dmpk plays an active role. The compound can be a transcription modulator molecule having a first terminus, a second terminus, and oligomeric backbone, wherein: a) the first terminus comprises a DNA-binding moiety capable of noncovalently binding to a nucleotide repeat sequence CAG or CTG; b) the second terminus comprises a protein-binding moiety binding to a regulatory molecule that modulates an expression of a gene comprising the nucleotide repeat sequence CAG or CTG; and c) the oligomeric backbone comprising a linker between the first terminus and the second terminus.

Harnessing the E3 Ligase KEAP1 for Targeted Protein Degradation

Chen, He,Chen, Xian,Jin, Jian,Kumar, Prashasti,Li, Dongxu,Meng, Fanye,Park, Kwang-Su,Shen, Yudao,Teichman, Emily,Velez, Julia,Wang, Gang Greg,Wang, Li,Wei, Jieli,Xie, Ling,Yim, Hyerin,Kaniskan, H. ümit

supporting information, p. 15073 - 15083 (2021/10/01)

Proteolysis targeting chimeras (PROTACs) represent a new class of promising therapeutic modalities. PROTACs hijack E3 ligases and the ubiquitin-proteasome system (UPS), leading to selective degradation of the target proteins. However, only a very limited number of E3 ligases have been leveraged to generate effective PROTACs. Herein, we report that the KEAP1 E3 ligase can be harnessed for targeted protein degradation utilizing a highly selective, noncovalent small-molecule KEAP1 binder. We generated a proof-of-concept PROTAC, MS83, by linking the KEAP1 ligand to a BRD4/3/2 binder. MS83 effectively reduces protein levels of BRD4 and BRD3, but not BRD2, in cells in a concentration-, time-, KEAP1- and UPS-dependent manner. Interestingly, MS83 degrades BRD4/3 more durably than the CRBN-recruiting PROTAC dBET1 in MDA-MB-468 cells and selectively degrades BRD4 short isoform over long isoform in MDA-MB-231 cells. It also displays improved antiproliferative activity than dBET1. Overall, our study expands the limited toolbox for targeted protein degradation.

Potent Dual BET/HDAC Inhibitors for Efficient Treatment of Pancreatic Cancer

Dong, Guoqiang,He, Shipeng,Li, Yu,Sheng, Chunquan,Wang, Wei,Wu, Shanchao

supporting information, p. 3028 - 3032 (2020/02/11)

As one of the most aggressive and lethal human malignancies with extremely poor prognosis, there is an urgent demand of more effective therapy for the treatment of pancreatic cancer. Reported here is a new, effective therapeutic strategy and the design of small-molecule inhibitors that simultaneously target bromodomain and extra-terminal (BET) and histone deacetylase (HDAC), potentially serving as promising therapeutic agents for pancreatic cancer. A highly potent dual inhibitor (13 a) is identified to possess excellent and balanced activities against BRD4 BD1 (IC50=11 nm) and HDAC1 (IC50=21 nm). Notably, this compound shows higher in vitro and in vivo antitumor potency than the BET inhibitor (+)-JQ1 and the HDAC inhibitor vorinostat, either alone or and in combination, highlighting the advantages of BET/HDAC dual inhibitors for more effective treatment of pancreatic cancer.

MALE CONTRACEPTIVE COMPOSITIONS AND METHODS OF USE

-

Page/Page column 85, (2011/12/02)

The invention relates to compositions and methods for effecting male contraception.

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