- Synthesis of novel γ-ketoesters from succinic anhydride
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Four alkyl g-ketohexanoates (3a-3d) have been prepared from succinic anhydride employing a three step reaction strategy. In the first step using p-toluene sulfonic acid as catalyst, the ring of succinic anhydride was opened with isopropyl, isobutyl, isopentyl and benzyl alcohols, respectively to form alkyl hydrogen succinates (1a-1d). In the 2nd step these alkyl hydrogen succinates on treatment with SOCl2 yielded 4-alkoxy-4-ketobutanoyl chlorides (2a-2d). The acid halides thus obtained, on reaction with diethyl cadmium led to require g-ketoesters. All the synthesised compounds were characterized by recording and analyzing 1H, 13C NMR, IR spectra and mass measurements.
- Iqbal, Muhammad,Baloch, Imam Bakhsh,Baloch, Musa Kaleem
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p. 9701 - 9703
(2014/01/06)
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- Acetazolamide-related compounds, process for their preparation, and pharmaceutical composition containing the same
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Compounds related to acetazolamide and to its N-methyl derivatives, of the formulae: STR1 wherein Y is one of the following groups: STR2 R1 being a straight or branched alkylene or arylalkylene, or a phenylene, and the processes for their preparation; the compounds so obtained are inhibitors of carbonic anhydrase like acetazolamide but, in addition, they are well absorbed topically so that they can be used as drugs for treating glaucoma.
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