- Ultrasound Assisted Synthesis of Some Novel Bis-Pyridazine Derivatives
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Bis-enaminone 3 was coupled with aryldiazonium chlorides 4a, 4b to afford the bis-arylhydrazonopropanals 6a, 6b. Compounds 6a, 6b could be utilized for the synthesis of a variety of bis-(dimethyl 2,3-dihydropyridazine-3,4-dicarboxylate), bis-(pyridazin-3(
- Mekky, Ahmed E. M.,Al-Bogami, Abdullah S.
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- Efficient Synthesis of New Benzofuran-based Thiazoles and Investigation of their Cytotoxic Activity Against Human Breast Carcinoma Cell Lines
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A new series of 1,3-thiazole-benzofuran derivatives was synthesized via heterocyclization of 2-(1-(6-alkoxy-4,7-dimethoxybenzofuran-5-yl)ethylidene)-2-methyl-2l4-diazane-1-carbothioamides with hydrazonoyl halides. Also, 1-(4,7-dimethoxybenzofuran-5-yl)-3-
- Gomha, Sobhi M.,Abdelhamid, Abdou O.,Abdelrehem, Nadia A.,Kandeel, Sahar M.
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- Novel method for the synthesis of 6,12-dihydro-2-methylindolo[2,3- b]carbazol-6-ones
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A novel method for the synthesis of 6,12-dihydro-2-methylindolo[2,3-b] carbazol-6-ones was developed from 1-oxo-2,3,4,9-tetrahydro-1H-carbazol-1-one through methyl 6-methyl-2-(1-oxo-2,3,4,9-tetrahydro-1H-carbazol-2-yl)oxoacetate in good yields. This metho
- Ebenezer Martin,Prasad, K. J. Rajendra
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Read Online
- A comprehensive spectroscopic, solvatochromic and photochemical analysis of 5-hydroxyquinoline and 8-hydroxyquinoline mono-azo dyes
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A series of novel substituted-azo dyes 8-(aryldiazenyl)quinolin-5-ol (5a-i) were synthesized by the coupling reaction of 5-hydroxyquinoline with diazotized aniline derivatives in the presence of NaNO2 in HCl/H2O mixture. The study of
- Coelho, Paulo J.,Lup, Andrew Ng Kay,Mahon, Peter J.,Pesyan, Nader Noroozi,Ramezanitaghartapeh, Mohammad,Raposo, M. Manuela M.,Rashidnejad, Hamid,Soltani, Alireza
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- Synthesis and antioxidant assay of new nicotinonitrile analogues clubbed thiazole, pyrazole and/or pyridine ring systems
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A series of novel nicotinonitrile derivatives were synthesized by hybridization with thiazole, pyrazole, and pyridine ring systems using 4-aminobenzohydrazide as link-bridge. The synthetic strategy of nicotinonitrile-thiazole analogues involves cyclizatio
- Abumelha, Hana M. A.
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- Synthesis and Pharmacological Investigations of Novel Pyrazolyl and Hydrazonoyl Cyanide Benzimidazole Entities
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Various novel benzimidazole entities linked to pyrazolyl and hydrazonoyl cyanide substrates carrying aryl and heteroaryl groups (8a–e to 10a–e) were synthesized using new route syntheses and were focused on their pharmacological evaluation as one of the m
- Khalifa, Mohamed E.,Gobouri, Adil A.,Kabli, Fahad M.,Altalhi, Tariq A.,Almalki, Abdulraheem S. A.,Elemshaty, Amira M.
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p. 1426 - 1436
(2019/04/17)
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- New Thiophene Derivatives as Antimicrobial Agents
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Phenacylbromide derivatives constitute a multilateral group of precursors for the synthesis of numerous heterocycles of organic compounds. Briefly, 5-(2-bromo-acetyl)-substituted-thiophene derivative has been used as a synthon for synthesis of new thiophene-containing compounds through the reaction with nucleophilic nitrogen compounds and thioamides. The suggested structures of the newly synthesized thiophene compounds were confirmed and assured with different spectroscopic tools and with CHN elemental analysis. Additionally, the antimicrobial activity of these thiophene compounds was recorded to investigate their potency against various types of bacteria and fungi. Results showed that these compounds exhibit significant inhibitory activity against the growth of tested bacterial and fungal strains and that some derivatives were more potent than the employed reference drugs.
- Mabkhot, Yahia Nasser,Kaal, Nahed Ahmed,Alterary, Seham,Mubarak, Mohammad S.,Alsayari, Abdulrhman,Bin Muhsinah, Abdullatif
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p. 2845 - 2953
(2019/08/26)
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- Norbornadienes: Robust and Scalable Building Blocks for Cascade "click" Coupling of High Molecular Weight Polymers
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Herein, we report the development of a scalable and synthetically robust building block based on norbornadiene (NBD) that can be broadly incorporated into a variety of macromolecular architectures using traditional living polymerization techniques. By tak
- St Amant, Andre H.,Discekici, Emre H.,Bailey, Sophia J.,Zayas, Manuel S.,Song, Jung-Ah,Shankel, Shelby L.,Nguyen, Shay N.,Bates, Morgan W.,Anastasaki, Athina,Hawker, Craig J.,De Alaniz, Javier Read
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supporting information
p. 13619 - 13624
(2019/09/10)
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- 3-Aminopyrazolo[4,3-c]pyridine-4,6-dione as a precursor for novel pyrazolo[4,5,1-ij][1,6]naphthyridines and pyrido[4’,3’:3,4]pyrazolo[1,5-a]pyrimidines
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The versatile, 3-aminopyrazolo[4,3-c]pyridine-4,6-dione (2) was synthesized and allowed to react with aldehydes, aryldiazonium chlorides, chalcones and enaminones to afford regioselectively the novel pyrazolo[4,3-c]pyridine derivatives 4a-c, pyrazolo[4,5,
- Metwally, Nadia H.,Deeb, Emad A.
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supporting information
p. 1614 - 1628
(2018/06/14)
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- (E)-N-Aryl-2-oxo-2-(3,4,5-trimethoxyphenyl)acetohydrazonoyl cyanides as tubulin polymerization inhibitors: Structure-based bioisosterism design, synthesis, biological evaluation, molecular docking and in silico ADME prediction
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A series of (E)-N-Aryl-2-oxo-2-(3,4,5-trimethoxyphenyl)acetohydrazonoyl cyanides have been synthesized and evaluated for their anticancer activity in human hepatocellular liver carcinoma HepG2 and breast adenocarcinoma MCF-7 cell lines. Among all the test
- Wang, Guangcheng,Peng, Zhiyun,Peng, Shanshan,Qiu, Jie,Li, Yongjun,Lan, Yanyu
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supporting information
p. 3350 - 3355
(2018/09/12)
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- Containing chrysanthemic acid structure pyrazole compound and its preparation method and use thereof
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The invention discloses a pyrazole compound containing chrysanthemic acid structure and a preparation method and purpose of the pyrazole compound with the general structural formula (I). The definition of each substituent group in the general structural formula (I) is showed in the description and claims. The pyrazole compound is good in insect killing effect, simple in production process and high in yield.
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Paragraph 0051; 0052; 0053
(2018/11/03)
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- Frozen aryldiazonium chlorides in radical reactions with alkenes and arenes
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Frozen aryldiazonium chlorides have been investigated in radical alkene and arene functionalizations. Through freezing at – 84 °C, aryldiazonium chlorides, which otherwise show significant decomposition in aqueous solution after several hours at room temp
- Thon, Daniel,Fürst, Michael C.D.,Altmann, Lisa-Marie,Heinrich, Markus R.
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p. 5289 - 5294
(2018/07/06)
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- PROCESS FOR THE SYNTHESIS OF ARYLDIAZONIUM SALTS USING NITROGEN OXIDES IN OXYGEN-CONTAINING GAS STREAMS, ESPECIALLY FROM INDUSTRIAL WASTE GASES
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The present invention relates to a process for the synthesis of aryldiazonium salts using nitrogen oxides in oxygen-containing gas streams, especially from industrial waste gases.
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Page/Page column 35; 36; 37; 38; 39
(2017/06/30)
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- New 2-pyrone-based hydrazones: Synthesis, spectral characterisation, UV–visible study and evaluation of the antiradicalar activity
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The synthesis of new 2-pyrone-based hydrazones has been prepared by the coupling of 6-methyl-2H-furo[3,2-c]pyran-3,4-dione with diazonium salts, obtained by diazotization of aniline derivatives. The structure of all compounds was established by spectrosco
- Oukacha-Hikem, Djamila,Makhloufi-Chebli, Malika,Amar, Anissa,Bouherrou, Houria,Rachedi, Yahia,Meghezzi, Hacène,Silva, Artur M. S.,Hamdi, Maamar
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supporting information
p. 590 - 598
(2017/03/15)
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- Synthesis and characterization of new pyrazole-based thiazoles
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A series of new 5-(heteroaryldiazenyl)thiazole incorporating pyrazole moiety have been synthesized through coupling of the thiazole with the appropriate heteroaryldiazonium salts. The newly synthesized compounds were characterized by elemental analysis, s
- Abdelhamid, Abdou O.,Gomha, Sobhi M.
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supporting information
p. 1409 - 1414
(2017/07/25)
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- Total chemical synthesis method of adenine
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The invention relates to a total chemical synthesis method of adenine. The method comprises the following steps of: 1) dissolving primary amine in strong-acid solution, dripping sodium nitrite solution to prepare diazonium salt, adding malononitrile for dissolving, and dripping alkaline solution to regulate a pH value of reaction solution and generate coupling reaction, thereby obtaining an azo compound; 2) adding the azo compound into formamide, and introducing liquid ammonia, heating to carry out high-temperature condensation and cyclization reaction, thereby obtaining a pyrimidine-azo compound; 3) dissolving the pyrimidine-azo compound into water, adding a catalyst, and introducing hydrogen for hydrogenation, thereby obtaining 4,5,6-triamidopyrimidine; and 4) dissolving the 4, 5, 6-triamidopyrimidine into the formamide to carry out high-temperature cyclization with the formamide, thereby obtaining an adenine crude product, and after recrystallization, obtaining white crystalline powder, i.e., a high-purity refined adenine product. The total chemical synthesis method has the advantages that water is used as a solvent in the step 1), and solvents used in the steps 2), 3) and 4) can be repeatedly used, so that the 'three wastes' are fewer, and the environment-friendly effect is achieved; and the total yield is 64.75% (calculated according to the amount of malononitrile), and the cost is low, so that the industrialization is easy and the economic benefit is obvious.
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Paragraph 0021
(2017/08/29)
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- Design, synthesis and anticancer activity of some novel 5-(4-methoxyphenyl)-2,4-dihydro-3H-pyrazol-3-one derivatives
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New pyrazole derivatives were designed and synthesized by the reaction of 5-(4-methoxyphenyl)-2,4-dihydro-3H-pyrazol-3-one (4) or 5-(4-methoxyphenyl)-2-phenyl-2,4-dihydro-3H-pyrazol-3-one (5) with series of aldehydes, substituted amines, isatins and phenylisothiocynate to yield 6a-j, 7a-k, 9a-d and 10a-b, respectively. The synthesized compounds were examined in vitro for their anti-tumor activities against HepG-2, PC-3 and HCT-116 human carcinoma cell lines using MTT assay. Eight compounds showed good anticancer activities against HCT-116 carcinoma cells and five compounds showed good anticancer activities against PC-3 cancer cells but all the compounds showed weak or no anticancer activities against HepG-2 liver cancer.
- Fathy, Usama,Gouhar, Rasha S.,Awad, Hanem M.
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p. 1427 - 1436
(2017/10/23)
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- Aminothiazoles as Potent and Selective Sirt2 Inhibitors: A Structure-Activity Relationship Study
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Sirtuins are NAD+-dependent protein deacylases that cleave off acetyl but also other acyl groups from the ε-amino group of lysines in histones and other substrate proteins. Dysregulation of human Sirt2 (hSirt2) activity has been associated with the pathogenesis of cancer, inflammation, and neurodegeneration, which makes the modulation of hSirt2 activity a promising strategy for pharmaceutical intervention. The sirtuin rearranging ligands (SirReals) have recently been discovered by us as highly potent and isotype-selective hSirt2 inhibitors. Here, we present a well-defined structure-activity relationship study, which rationalizes the unique features of the SirReals and probes the limits of modifications on this scaffold regarding inhibitor potency. Moreover, we present a crystal structure of hSirt2 in complex with an optimized SirReal derivative that exhibits an improved in vitro activity. Lastly, we show cellular hyperacetylation of the hSirt2 targeted tubulin caused by our improved lead structure.
- Schiedel, Matthias,Rumpf, Tobias,Karaman, Berin,Lehotzky, Attila,Oláh, Judit,Gerhardt, Stefan,Ovádi, Judit,Sippl, Wolfgang,Einsle, Oliver,Jung, Manfred
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p. 1599 - 1612
(2016/03/05)
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- Synthesis, in vitro and in Silico studies of some novel 5-nitrofuran-2-yl hydrazones as antimicrobial and antitubercular agents
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In this study, we synthesized two series of novel 5-nitrofuran-2-carbohydrazides 21a-h and 22a-e in addition to a third series of thiophene-2-carbohydrazides 23a-g to develop potent antimicrobial and/or antitubercular agents. The newly synthesized compounds were evaluated in vitro for their antimicrobial and antimycobacterial activities. Most of the 5-nitrofuran-2-carbohydrazides 21a-h and 22a-e displayed variable activity against Aspergillus fumigates, Staphylococcus aureus, Streptococcus pneumonia, Bacillis subtilis, Salmonella typhimurium, Klebsiella pneumonia, Escherichia coli and Mycobacterium tuberculosis. The sulfonamide derivative 21f exhibited superior potency and broad-spectrum antimicrobial activity with minimum inhibitory concentration (MIC)=0.06-0.98 μg/mL and antimycobacterial activity with MIC=3.9 μg/mL. The 5-nitrofuran-2-carbohydrazides 21a, b, g, h and 22a-c exhibited significant antibacterial activity with MIC values in the range of 0.12-7.81 μg/mL. The significances of the 5-nitrofuran moiety and sulfonamide function were explored via the structure-activity relationship (SAR) study. In addition, docking studies revealed that the p-amino benzoic acid (PABA) and binding pockets of the dihydropteroate synthase (DHPS) were successfully occupied by compound 21f. Furthermore, two quantitative structure-activity relationship (QSAR) models were built to explore the structural requirements which controlled the activity.
- Abdel-Aziz, Hatem Abdel-Kader,Eldehna, Wagdy Mohamed,Fares, Mohamed,Elsaman, Tilal,Abdel-Aziz, Marwa Mostafa,Soliman, Dalia Hussein
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p. 1617 - 1630
(2015/11/24)
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- Synthesis of novel benzimidazole and benzothiazole derivatives
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1-(Benzothiazol-2-yl)-2-phenylsulfonyl-1-ethanone (1) and 1-(1-methyl-1H-benzimidazol-2-yl)-2-(phenylsulfonyl)-1-ethanone (2) were used as potential scaffolds for biologically interesting azoloazine derivatives via their reaction with the diazonium salts
- Darweesh, Ahmed F.,Mekky, Ahmed E. M.,Salman, Amani A.,Farag, Ahmad M.
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p. 113 - 125
(2014/02/14)
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- Synthesis of progesterone derivatives and evaluation of their efficiency as pneumococcal vaccines
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Progesterone (1) was used as a template to develop new anticancer compounds. Ring D modification of 1, through its reaction with active methylene derivatives, gave the condensate derivatives 3a, b. The latter compounds underwent heterocyclization reaction
- Mohareb, Rafat M.,Al Farouk, Fatma O.,Sherif, Sherif M.,Karaghiosoff, Konstantin
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p. 3165 - 3177
(2014/05/06)
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- Heterocyclic ring extension of estrone: Synthesis and cytotoxicity of fused pyran, pyrimidine and thiazole derivatives
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The one pot reaction of estrone with the aromatic aldehydes 2a-c and either of malononitrile or ethyl cyanoacetate afforded the fused pyran derivatives 4a-f. On the other hand, carrying the same reaction using thiourea instead of the cyanomethylene reagent gave the fused pyrimidine derivatives 6a-c. The latter compounds reacted with phenacyl bromide to give the thiazolo[3,2-a] pyrimidine derivatives 8a-c. The reaction of the title compound with bromine gave the monobromo derivative 13 which in turn reacted with either thiourea or cyanothioacetamide to give the thiazole derivatives 14 and 16, respectively. The cytotoxicity of the newly synthesized products was evaluated against six human cancer and normal cell lines where the results showed that compounds 4c, 4f, 6b, 8b, 8c, 10, 13, 16, 18c and 19c exhibited optimal cytotoxic effect against the cancer cell lines, with IC50's in the nM range.
- Mohareb, Rafat M.,Al-Omran, Fatima,Azzam, Rasha A.
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- New fluorescent symmetrically substituted perylene-3,4,9,10-dianhydride- azohybrid dyes: Synthesis and spectroscopic studies
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Five phenolic azo-dyes (3a-e) were synthesized by diazo coupling of the suitably substituted anilines (1a-e) with phenol at low temperature in alkaline medium. The resulting dyes have low solubility in aqueous medium due to lack of carboxylic or sulfonic
- Saeed, Aamer,Shabir, Ghulam
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- Synthesis and antibacterial activity of some novel 4-aryl hydrazono-2,5-disubstituted-2,4-dihydro-3H-pyrazol-3-ones
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4-Aryl hydrazono-2,4-dihydro-3H-pyrazol-2,5-disubstituted-3-ones were prepared by the reaction of ethyl-2-arylhydrazono-3-oxybutyrates with substituted hydrazines in the presence of glacial acetic acid at reflux temp. The synthesized compounds have been c
- Singh, Vipin Kumar
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p. 429 - 432
(2019/01/21)
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- Synthesis, characterization, and electrochemical study of some novel, azo-containing Schiff bases and their Ni(II) complexes
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Five novel azo-azomethine ligands with NN'OS coordination spheres were prepared by reaction of methyl-2-{N-(2′-aminoethane)}-amino-1- cyclopentenedithiocarboxylate (Hcden) with (E)-2-hydroxy-5-(phenyldiazenyl) benzaldehyde and its substituted derivatives
- Menati, Saeid,Azadbakht, Azadeh,Azadbakht, Reza,Taeb, Abbas,Kakanejadifard, Ali
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p. 499 - 506
(2013/07/27)
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- Di-substituted azocalix[4]arenes containing chromogenic groups: Synthesis, characterization, extraction, and thermal behavior
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In this study, the synthesis of chromogenic di-substituted azocalix[4]arene derivatives is described. Six novel azocalix[4]arenes (4a-f)were prepared by linking 4-methoxy, 4-methyl, 4-ethyl, 4-chloro, 4-bromo, and 4-nitroaniline to 25,26,27,28-tetrahydrox
- El?in, Serkan,Delig?z, Hasalettin
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p. 6832 - 6838
(2013/07/26)
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- Synthesis and antimicrobial effects of 1,3,5-substituted phenyl formazans
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In this study, novel formazans with various substituents on 1,3,5-phenyl rings were synthesized and their structures were elucidated with the use of elemental analysis, mass,1H NMR,13C NMR, IR, UV-VIS spectra. Also, antimicrobial effects of formazans were tested against selected microorganism, Staphylococus aureus, S. epidermidis, S. saprophyticus, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae. Moreover, the antiyeast effects of the formazans are seen on the Candida kefir, C. glabrata, C. tropicalis, Cryptococcus neofarmans, Saccharomyces cerevisiae. In the present study, it was generally observed that the formazans were very active against Candida kefir, C. tropicalis, Cryptococcus neofarmans and Saccharomyces cerevisiae.
- Uraz, Guven,Yilmaz, Ebru,Tezcan, Habibe,Porsuk, Nesrin,Imamoglu, Gamze,Kartli, Onur Savas
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experimental part
p. 1924 - 1926
(2012/09/07)
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- Synthesis and antibacterial activity of some new S-triazole derivatives
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Alkylation of 4-anilino-5-phenyl-4H-1,2,4-triazole-3-thiol (1) with some halo compounds yielded the corresponding sulfides 2a-f. Some sulfides 2e,f were cyclized to give triazolothiadiazines 3 and 4. Triazolothiadiazoles 5 and 6 were prepared through the reaction of compound 1 with carbon disulfide or ethyl orthoformate, respectively. Treatment of compound 1 with ethyl chloroformate or phenyl isothiocyanate yielded triazolo-thiadiazole and triazole 9 and 10, respectively. Reaction of compound 1 with Lawesson's reagent gave triazolothiadiazaphosphole derivative 11. Also, compound 1 underwent cyclocondensation reactions with some bidentate reagents to give triazolothiazines 4, 12, and 13. Triazolo-thiazepines and triaziepine 14-16 were synthesized via the reaction of compound 1 with -ketoesters or ethyl cyanoacetate. Tricyclic systems 19 and 20 were prepared through the reaction of compound 4 with the appropriate reagent. Some synthesized compounds were tested for antibacterial activity. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.
- Ghattas, Abd El-Badih A. G.,Moustafa, Hassan M.,Hassanein, Elsayed A. A.,Hussein, Bahgat R. M.
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p. 1469 - 1481
(2012/11/06)
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- Heterocyclizations of pregnenolone: Novel synthesis of thiosemicarbazone, thiophene, thiazole, thieno[2,3-b]pyridine derivatives and their cytotoxicity evaluations
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Pregnenolone (1) was used as a template to develop new anticancer compounds. Ring D modification of 1 through its reaction with 4-phenyl-3-thiosemicarbazide gave the thiosemicarbazone derivative 3. The latter compound underwent heterocyclization reactions
- Mohareb, Rafat M.,Wardakhan, Wagnat W.,Elmegeed, Gamal A.,Ashour, Rehab M.S.
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p. 1560 - 1569
(2013/01/15)
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- Reaction with hydrazonoyl halides 64: Synthesis of some new triazolino[4,3-a]pyrimidines, 1,3,4-thiadiazoles, and 5-arylazothiazoles
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2,3-Dihydro-1,3,4-thiadiazoles, 2,3-dihydro-1,3,4-selenadiazoles, and triazolino[4,3-a]pyrimidines containing benzofuran moiety were prepared from the reaction of 2-(2-phenylhydrazono)-1-(5-bromobenzofuran-2-yl)-2-chloroethanone with each of potassium thi
- Abdelhamid, Abdou O.,Fahmi, Abdelgawad A.,Baaui, Basma S.
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p. 1098 - 1107,10
(2020/10/15)
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- Microwave assisted synthesis and unusual coupling of some novel pyrido[3,2-f][1,4]thiazepines
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3-Amino-3-thioxopropanamide (1) reacted with ethyl acetoacetate to form 6-hydroxy-4-methyl-2-thioxo-2,3-dihydropyridine-3-carboxamide (2), which reacted with α-haloketones 3 to produce 2,3-disubstituted-8-hydroxy-6-methyl-2H, 5H-pyrido[3,2-f]- [1,4]thiaze
- Faty, Rasha M.,Youssef, Mohamed M.,Youssef, Ayman M.S.
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experimental part
p. 4549 - 4559
(2011/08/06)
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- Synthesis and crystal structure of (5-methyl-3-phenyl-1h-pyrazol-1-yl)-[5- (p-tolylamino)-2h-1,2,3-triazol-4-yl]methanone
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(5-Methyl-3-phenyl-1H-pyrazol-1-yl)-[5-(p-tolylamino)-2H-1,2, 3-triazol-4-yl]methanone was synthesized and characterized by 1H NMR, MS and IR spectra data. The structure of title compound was identified by X-ray diffraction. Compound, C20
- Cao, Zi-Ping,Dong, Hong-Ru,Shen, Guo-Liang,Dong, Heng-Shan
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scheme or table
p. 1078 - 1081
(2011/08/22)
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- A convenient route to new pyrrolo[1,2-c]pyrimidone, thiazolo[3,4-c]pyrimidone and pyrimido[4,5-d]pyriadazine derivatives
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The utility of versatile, readily accessible ethyl 6-bromomethyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate (3) and ethyl 6-bromomethyl-2-oxo-4-phenyl-1,2-dihydropyrimidine-5-carboxylate (4) in the synthesis of some new pyrimidine, pyrimido[4,5-d]pyridazine, pyrrolo[1,2-c]pyrimidone and thiazolo[3,4-c]pyrimidone derivatives is reported.
- Kheder, Nabila A.,Mabkhot, Yahia N.,Farag, Ahmad M.
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experimental part
p. 937 - 946
(2009/09/30)
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- Tetracyclic compounds from 1-oxo-1,2,3,4,5,6-hexahydrocycloocta[b]indole. Synthesis of oxazolo[4′5′:8,7]cycloocta[b]indoles
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Japp-Klingmann method was used to diazotise aniline derivatives and 2-hydroxymethylenecyclooctanone 2 to obtain cyclooctan-1′,2′ -dione-1′-arylhydrazone 3 which upon acid cyclisation using kents reagent gave 1-oxo-1,2,3,4,5,6-hexahydrocycloocta[b]indole 4
- Vandana,Velumani,Prasad, K. J. Rajendra
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p. 299 - 306
(2007/10/03)
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- Synthesis, characterization and antimicrobial studies of some novel 3- arylazo-7-hydroxy-4-methylcoumarins
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A series of 3-arylazo-7-hydroxy-4-methylcoumarins have been synthesized in excellent yields (80-90%) and their structures established on the basis of IR, 1H NMR, mass spectral data and elemental analyses. Their purity has been ascertained by ch
- Sharma, Pratibha,Pritmani, Shreeya
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p. 1139 - 1142
(2007/10/03)
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- Reaction of Triazene 1-Oxides: Novel Synthesis of Solid Arenediazonium Chlorides
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Treatment of 1,3-diaryltriazene 1-oxides with oxalyl chloride in dry toluene at room temperature gives only solid arenediazonium chlorides; however, treatment with acetyl and benzoyl chlorides does not afford the corresponding diazonium chlorides.
- Mohamed, Shaaban K.,Gomaa, Mohsen A.-M.,Nour El-Din, Ahmed M.
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p. 166 - 167
(2007/10/03)
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- Synthesis of novel tryptamine and azepinoindole derivatives
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A novel one-pot synthesis of azepinoindoles (9) via reaction of tryptamines (4) with formaldehyde is described. The scope and generality of this new procedure and the preparation of the starting compounds are also discussed.
- Novak, Lajos,Hanania, Michel,Kovacs, Peter,Rohaly, Janos,Kolonits, Pal,Szantay, Csaba
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p. 2331 - 2347
(2007/10/03)
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- New Syntheses of Pyrazolopyrimidine, Pyrazolopyridazine, Isoindolinedione and Pyrazole Derivatives
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Phenacylmalononitriles 2 react with hydrazines, acetic-hydrochloric acid and with diazotised primary aromatic amines to afford phenacylpyrazole (5a,b), aminofurans (6a,b) and aminopyrazole derivatives (3a,d) respectively.The synthesised derivatives (3d,6a
- Abdelhamid, Abdou O.,Negm, Abdalla M.,Abbas, Ikhlass M.
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- Synthesis and Pharmacology of Some New Oxime Ethers Derived from 2-Acetyl-5-arylthiophenes
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Several new 5-arylthiophene-2-acetoxime ethers (1-28) have been synthesised and screened for their pharmacological activities.Some of these compounds possess moderate antiinflammatory and mild CNS depressant activities.The intermediate 2-acetyl-5-(p-ethyl/p-iso-propyl/3,4-dimethylphenyl)thiophenes (1b-d) and their oximes (IIb-d) have been reported for the first time.
- Shridhar, D. R.,Sastry, C. V. Reddy,Chaturvedi, S. C.,Gurumurthy, R.,Singh, P. P.,et al.
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p. 692 - 694
(2007/10/02)
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- Substituent Effects on 13C and 15N Chemical Shifts in Triazenes Studied by Principal Components Multivariate Data Analysis
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Principal components analysis was applied to the 13C and 15N chemical shift data on a series of fifteen 1-(para-substituted-phenyl)-3-acetyl-3-methyltriazenes.It was found that the halogen-substituted triazenes formed a class, based on substituent effects, which was different from the remaining eleven triazenes.A one-component model described the halogen class, whereas a two-component model was necessary for a description of the second class.In the second class, substituent tended to cluster to form groups depending on their electronic character.
- Dunn, III, W.J.,Lins, C.,Kumar, G.,Manimaran, T.,Grigoras, S.,et al.
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p. 450 - 456
(2007/10/02)
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- 1,2,3-Triazabutadienes. XIV. Investigations into the Acidic Cleavage of the Z-E-Isomeric 1-Aryl-3-- and 1-Aryl-3--triazenes
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The rate of the acid cleavage of the Z-E-isomeric 1-aryl-3-- and 1-aryl-3--triazenes 1 - 5 is investigated in dependence on the substituents in the aryl and benzo residue.The Z-isomer
- Fanghaenel, E.,Hohlfeld, J.
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p. 253 - 261
(2007/10/02)
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- Polarography of Some Arylazothiohydantoin Derivatives
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The polarographic behaviour of a series of arylazothiohydantoin derivatives has been investigated at a dropping mercury electrode.Two wawes were displayed.The first and predominant one is due to the reductive splitting of the azo-linkage by a 4e irreversi
- Darwish, S.,Fahmy, H. M.,Abdel Aziz, M. A.,El Maghraby, A. A.
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p. 344 - 349
(2007/10/02)
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- Novel anti-inflammatory pyrazole derivatives and preparation thereof
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Pyrazole compounds of the formula STR1 wherein n is 1, 2, 3, or 4; R1, R2, R3, and R4, which can be in the ortho, meta or para position, each are hydrogen, halogen, alkyl, alkoxy, trifluoromethyl, nitro or amino
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